Video-evoked neuromarkers of visual function in age-related macular degeneration
Neural markers of visual function in age-related macular degeneration (AMD) allow clinicians and researchers to directly evaluate the functional changes in visual processing which occur as a result of the progressive loss of afferent input from the macula. Unfortunately, few protocols exist that eli...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1569282/full |
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| author | Angela I. Renton David J. Klein Jesse A. Livezey Dan Nemrodov Stephanie Wolfer Adam Hanina Dimitri Van De Ville Dimitri Van De Ville |
| author_facet | Angela I. Renton David J. Klein Jesse A. Livezey Dan Nemrodov Stephanie Wolfer Adam Hanina Dimitri Van De Ville Dimitri Van De Ville |
| author_sort | Angela I. Renton |
| collection | DOAJ |
| description | Neural markers of visual function in age-related macular degeneration (AMD) allow clinicians and researchers to directly evaluate the functional changes in visual processing which occur as a result of the progressive loss of afferent input from the macula. Unfortunately, few protocols exist that elicit such neural markers, and most of these are poorly adapted to AMD. Here, we propose a novel method of embedding frequency tags into full color and motion videos by periodically manipulating the contrast of visual information of different spatial frequencies at different temporal frequencies. These videos elicit steady-state visual evoked potentials (SSVEPS) in viewers which, when measured using electrophysiological neuroimaging methods, independently represent the responses of populations of neurons tuned to the tagged spatial frequencies. We used electroencephalography (EEG) to record the SSVEPs of 15 AMD patients and 16 age-matched healthy controls watching a 6-min series of natural scene videos filtered with this spatial frequency tagging method. Compared with healthy controls, AMD patients showed a lower SSVEP to high spatial frequency information, and a stronger response to the low spatial frequency information in the video set. The ratio of the SSVEP to lower relative to higher spatial frequency information was strongly predictive of both visual acuity and contrast sensitivity, and the topographic distributions of these responses suggested retinotopic reorganization of the neural response to spatial frequency information. |
| format | Article |
| id | doaj-art-c490c089eecc4e2e982ffcc5a0f8b583 |
| institution | OA Journals |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-c490c089eecc4e2e982ffcc5a0f8b5832025-08-20T02:20:33ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-05-011910.3389/fnhum.2025.15692821569282Video-evoked neuromarkers of visual function in age-related macular degenerationAngela I. Renton0David J. Klein1Jesse A. Livezey2Dan Nemrodov3Stephanie Wolfer4Adam Hanina5Dimitri Van De Ville6Dimitri Van De Ville7Neuro-X Institute, School of Engineering, École polytechnique fédérale de Lausanne, Geneva, SwitzerlandDandelion Science Corp, Hoboken, NJ, United StatesDandelion Science Corp, Hoboken, NJ, United StatesDandelion Science Corp, Hoboken, NJ, United StatesDandelion Science Corp, Hoboken, NJ, United StatesDandelion Science Corp, Hoboken, NJ, United StatesNeuro-X Institute, School of Engineering, École polytechnique fédérale de Lausanne, Geneva, SwitzerlandDepartment of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandNeural markers of visual function in age-related macular degeneration (AMD) allow clinicians and researchers to directly evaluate the functional changes in visual processing which occur as a result of the progressive loss of afferent input from the macula. Unfortunately, few protocols exist that elicit such neural markers, and most of these are poorly adapted to AMD. Here, we propose a novel method of embedding frequency tags into full color and motion videos by periodically manipulating the contrast of visual information of different spatial frequencies at different temporal frequencies. These videos elicit steady-state visual evoked potentials (SSVEPS) in viewers which, when measured using electrophysiological neuroimaging methods, independently represent the responses of populations of neurons tuned to the tagged spatial frequencies. We used electroencephalography (EEG) to record the SSVEPs of 15 AMD patients and 16 age-matched healthy controls watching a 6-min series of natural scene videos filtered with this spatial frequency tagging method. Compared with healthy controls, AMD patients showed a lower SSVEP to high spatial frequency information, and a stronger response to the low spatial frequency information in the video set. The ratio of the SSVEP to lower relative to higher spatial frequency information was strongly predictive of both visual acuity and contrast sensitivity, and the topographic distributions of these responses suggested retinotopic reorganization of the neural response to spatial frequency information.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1569282/fullage-related macular degenerateion (AMD)visual functionneural markerfrequency taggingsteady-state visual evoked potentials (SSVEP)steerable wavelet pyramid |
| spellingShingle | Angela I. Renton David J. Klein Jesse A. Livezey Dan Nemrodov Stephanie Wolfer Adam Hanina Dimitri Van De Ville Dimitri Van De Ville Video-evoked neuromarkers of visual function in age-related macular degeneration Frontiers in Human Neuroscience age-related macular degenerateion (AMD) visual function neural marker frequency tagging steady-state visual evoked potentials (SSVEP) steerable wavelet pyramid |
| title | Video-evoked neuromarkers of visual function in age-related macular degeneration |
| title_full | Video-evoked neuromarkers of visual function in age-related macular degeneration |
| title_fullStr | Video-evoked neuromarkers of visual function in age-related macular degeneration |
| title_full_unstemmed | Video-evoked neuromarkers of visual function in age-related macular degeneration |
| title_short | Video-evoked neuromarkers of visual function in age-related macular degeneration |
| title_sort | video evoked neuromarkers of visual function in age related macular degeneration |
| topic | age-related macular degenerateion (AMD) visual function neural marker frequency tagging steady-state visual evoked potentials (SSVEP) steerable wavelet pyramid |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1569282/full |
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