PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways
The paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides. PON1 synthesis is upregulated by PPAR. Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/616371 |
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| author | Jordi Camps Anabel García-Heredia Anna Rull Carlos Alonso-Villaverde Gerard Aragonès Raúl Beltrán-Debón Esther Rodríguez-Gallego Jorge Joven |
| author_facet | Jordi Camps Anabel García-Heredia Anna Rull Carlos Alonso-Villaverde Gerard Aragonès Raúl Beltrán-Debón Esther Rodríguez-Gallego Jorge Joven |
| author_sort | Jordi Camps |
| collection | DOAJ |
| description | The paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides. PON1 synthesis is upregulated by PPAR. Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both PPAR activity and PON1 expression. Recent evidence suggests that PON1 and the monocyte chemoattractant protein-1 (MCP-1) are involved in coordinating the inflammatory response in damaged tissues; PPAR may be central in the regulation of these biochemical pathways. This article reviews the state of knowledge on PON1 biochemistry and function, the influence of genetic variation, and the regulation of PON1 expression by pharmaceutical compounds that increase PPAR activity. We also describe recent lines of evidence suggesting links between PON1 and MCP-1 and how their production may be regulated by PPAR. |
| format | Article |
| id | doaj-art-c48bd860345446a696b4217ee3329001 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-c48bd860345446a696b4217ee33290012025-02-03T05:58:29ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/616371616371PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation PathwaysJordi Camps0Anabel García-Heredia1Anna Rull2Carlos Alonso-Villaverde3Gerard Aragonès4Raúl Beltrán-Debón5Esther Rodríguez-Gallego6Jorge Joven7Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainCentre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43201 Reus, SpainThe paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides. PON1 synthesis is upregulated by PPAR. Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both PPAR activity and PON1 expression. Recent evidence suggests that PON1 and the monocyte chemoattractant protein-1 (MCP-1) are involved in coordinating the inflammatory response in damaged tissues; PPAR may be central in the regulation of these biochemical pathways. This article reviews the state of knowledge on PON1 biochemistry and function, the influence of genetic variation, and the regulation of PON1 expression by pharmaceutical compounds that increase PPAR activity. We also describe recent lines of evidence suggesting links between PON1 and MCP-1 and how their production may be regulated by PPAR.http://dx.doi.org/10.1155/2012/616371 |
| spellingShingle | Jordi Camps Anabel García-Heredia Anna Rull Carlos Alonso-Villaverde Gerard Aragonès Raúl Beltrán-Debón Esther Rodríguez-Gallego Jorge Joven PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways PPAR Research |
| title | PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways |
| title_full | PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways |
| title_fullStr | PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways |
| title_full_unstemmed | PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways |
| title_short | PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways |
| title_sort | ppars in regulation of paraoxonases control of oxidative stress and inflammation pathways |
| url | http://dx.doi.org/10.1155/2012/616371 |
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