Current Challenges in Bacterial Transcriptomics
Over the past decade or so, dramatic developments in our ability to experimentally determine the content and function of genomes have taken place. In particular, next-generation sequencing technologies are now inspiring a new understanding of bacterial transcriptomes on a global scale. In bacterial...
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| Format: | Article |
| Language: | English |
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BioMed Central
2013-06-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-76.pdf |
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| _version_ | 1832569554259148800 |
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| author | Suhyung Cho Yoobok Cho Sooin Lee Jayoung Kim Hyeji Yum Sun Chang Kim Byung-Kwan Cho |
| author_facet | Suhyung Cho Yoobok Cho Sooin Lee Jayoung Kim Hyeji Yum Sun Chang Kim Byung-Kwan Cho |
| author_sort | Suhyung Cho |
| collection | DOAJ |
| description | Over the past decade or so, dramatic developments in our ability to experimentally determine the content and function of genomes have taken place. In particular, next-generation sequencing technologies are now inspiring a new understanding of bacterial transcriptomes on a global scale. In bacterial cells, whole-transcriptome studies have not received attention, owing to the general view that bacterial genomes are simple. However, several recent RNA sequencing results are revealing unexpected levels of complexity in bacterial transcriptomes, indicating that the transcribed regions of genomes are much larger and complex than previously anticipated. In particular, these data show a wide array of small RNAs, antisense RNAs, and alternative transcripts. Here, we review how current transcriptomics are now revolutionizing our understanding of the complexity and regulation of bacterial transcriptomes. |
| format | Article |
| id | doaj-art-c48af75e3e084971945a5eed166802b4 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-c48af75e3e084971945a5eed166802b42025-02-02T20:35:59ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-06-01112768210.5808/GI.2013.11.2.7687Current Challenges in Bacterial TranscriptomicsSuhyung Cho0Yoobok Cho1Sooin Lee2Jayoung Kim3Hyeji Yum4Sun Chang Kim5Byung-Kwan Cho6Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Department of Biological Sciences and KAIST Institute for the BioCentury, Intelligent Synthetic Biology Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.Over the past decade or so, dramatic developments in our ability to experimentally determine the content and function of genomes have taken place. In particular, next-generation sequencing technologies are now inspiring a new understanding of bacterial transcriptomes on a global scale. In bacterial cells, whole-transcriptome studies have not received attention, owing to the general view that bacterial genomes are simple. However, several recent RNA sequencing results are revealing unexpected levels of complexity in bacterial transcriptomes, indicating that the transcribed regions of genomes are much larger and complex than previously anticipated. In particular, these data show a wide array of small RNAs, antisense RNAs, and alternative transcripts. Here, we review how current transcriptomics are now revolutionizing our understanding of the complexity and regulation of bacterial transcriptomes.http://genominfo.org/upload/pdf/gni-11-76.pdfantisense RNAnext-generation sequencingRNA sequencingsatellite RNAtranscription initiation sitetranscriptome |
| spellingShingle | Suhyung Cho Yoobok Cho Sooin Lee Jayoung Kim Hyeji Yum Sun Chang Kim Byung-Kwan Cho Current Challenges in Bacterial Transcriptomics Genomics & Informatics antisense RNA next-generation sequencing RNA sequencing satellite RNA transcription initiation site transcriptome |
| title | Current Challenges in Bacterial Transcriptomics |
| title_full | Current Challenges in Bacterial Transcriptomics |
| title_fullStr | Current Challenges in Bacterial Transcriptomics |
| title_full_unstemmed | Current Challenges in Bacterial Transcriptomics |
| title_short | Current Challenges in Bacterial Transcriptomics |
| title_sort | current challenges in bacterial transcriptomics |
| topic | antisense RNA next-generation sequencing RNA sequencing satellite RNA transcription initiation site transcriptome |
| url | http://genominfo.org/upload/pdf/gni-11-76.pdf |
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