Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification

Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification

Abstract The acidic tumor microenvironment, a hallmark of many solid tumors, is primarily induced by the high glycolytic rate of tumor cells. To avoid acidosis, tumor cells ingeniously maintain an acidic extracellular pH while keeping a relatively alkaline intracellular pH. Overturning the unique pH...

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Bibliographic Details
Main Authors: Qiufang Gong, Xuejiao Song, Yao Tong, Lixuan Huo, Xuefen Zhao, Yingying Han, Wei Shen, Jiaxi Ru, Xian Shen, Chao Liang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
Tumor microenvironment
Alkalization
Acidification
Nanomedicines
Anti-tumor therapy
Online Access:https://doi.org/10.1186/s12951-025-03134-2
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https://doi.org/10.1186/s12951-025-03134-2

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