Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid
We describe a rare infection with Nocardia spp. (N. pseudobrasiliensis species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. He was allergic to sulphonamide...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2018/1749691 |
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| _version_ | 1832554520295505920 |
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| author | George Mwandia Hari Polenakovik |
| author_facet | George Mwandia Hari Polenakovik |
| author_sort | George Mwandia |
| collection | DOAJ |
| description | We describe a rare infection with Nocardia spp. (N. pseudobrasiliensis species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. He was allergic to sulphonamides. He was initially successfully treated with linezolid. However, he suffered severe sensory neuropathy after 4 months of therapy, necessitating linezolid cessation and completion of treatment with azithromycin. He had clinical and radiological resolution of his pneumonia and was disease free at subsequent follow-up 4 years later. This case highlights the need for alternative therapies for nocardiosis for patients that cannot be treated with sulphonamides due to allergies or/and infection with multidrug-resistant pathogens. It also illustrates the treatment limiting side effects of long-term therapy with linezolid. |
| format | Article |
| id | doaj-art-c45d1e9b1d354652838abce341e7b970 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-c45d1e9b1d354652838abce341e7b9702025-02-03T05:51:20ZengWileyCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/17496911749691Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of LinezolidGeorge Mwandia0Hari Polenakovik1Wright State University Boonshoft School of Medicine, Weber CHE 2nd Floor, 128 Apple St., Dayton, OH 45419, USAWright State University Boonshoft School of Medicine, Weber CHE 2nd Floor, 128 Apple St., Dayton, OH 45419, USAWe describe a rare infection with Nocardia spp. (N. pseudobrasiliensis species identification based on high-performance liquid chromatography analysis) in a 68-year-old renal transplant recipient. He presented with pneumonia complicated by hypoxic respiratory failure. He was allergic to sulphonamides. He was initially successfully treated with linezolid. However, he suffered severe sensory neuropathy after 4 months of therapy, necessitating linezolid cessation and completion of treatment with azithromycin. He had clinical and radiological resolution of his pneumonia and was disease free at subsequent follow-up 4 years later. This case highlights the need for alternative therapies for nocardiosis for patients that cannot be treated with sulphonamides due to allergies or/and infection with multidrug-resistant pathogens. It also illustrates the treatment limiting side effects of long-term therapy with linezolid.http://dx.doi.org/10.1155/2018/1749691 |
| spellingShingle | George Mwandia Hari Polenakovik Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid Case Reports in Infectious Diseases |
| title | Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid |
| title_full | Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid |
| title_fullStr | Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid |
| title_full_unstemmed | Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid |
| title_short | Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid |
| title_sort | nocardia spp pneumonia in a solid organ recipient role of linezolid |
| url | http://dx.doi.org/10.1155/2018/1749691 |
| work_keys_str_mv | AT georgemwandia nocardiaspppneumoniainasolidorganrecipientroleoflinezolid AT haripolenakovik nocardiaspppneumoniainasolidorganrecipientroleoflinezolid |