Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery
Abstract Background Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR and PLR following obstructive sleep apnea (OSA) treatment were under studied and thus should be inv...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-07-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-023-00653-6 |
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| author | Chung-Wei Lin Pei-Wen Lin Li-Wen Chiu Han-Tan Chai Chun-Tuan Chang Michael Friedman Anna M. Salapatas Sara Rahavi-Ezabadi Hsin-Ching Lin |
| author_facet | Chung-Wei Lin Pei-Wen Lin Li-Wen Chiu Han-Tan Chai Chun-Tuan Chang Michael Friedman Anna M. Salapatas Sara Rahavi-Ezabadi Hsin-Ching Lin |
| author_sort | Chung-Wei Lin |
| collection | DOAJ |
| description | Abstract Background Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR and PLR following obstructive sleep apnea (OSA) treatment were under studied and thus should be investigated. This study aimed to evaluate the changes of inflammatory biomarkers including NLR and PLR in severe OSA patients after surgical interventions of the upper airway, and their relationships with improvements in polysomnographic (PSG) parameters. Methods This retrospective cohort study included 563 consecutive severe OSA patients at a tertiary academic medical center who received OSA surgery, as well as underwent pre- and post-operative polysomnographic (PSG) examinations and blood tests. The changes of major PSG estimates, NLR, and PLR before and at least 3 months after OSA surgery were analyzed using paired t-tests with subgroup analyses. Pearson’s correlations were performed to discover which PSG parameter contributed to the improvement of the values. Results After OSA surgery, the major PSG estimates, NLR and PLR dropped significantly in the overall population. In those with a higher preoperative NLR (pre-operative NLR≧3) and PLR (pre-operative PLR≧150), the mean (SD) difference of NLR (− 0.8 [1.6], 95% CI − 1.5 to − 0.2) and PLR (− 41.6 [40], 95% CI − 52.8 to − 30.5) were even more substantial. The changes of the “apnea, longest (r = 0.298, P = .037)” and “hypopnea, longest (r = 0.321, P = .026)” were found significantly related to the improvement of PLR. Conclusion NLR and PLR did significantly drop in severe OSA patients following OSA surgery, and this could be related to the alterations of sleep indices. The findings could possess clinical importance for severe OSA patients after OSA surgeries in reducing possible OSA-associated cardiovascular comorbidities. |
| format | Article |
| id | doaj-art-c457841159cd404c82d3c7eadc75fae2 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | SAGE Publishing |
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| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-c457841159cd404c82d3c7eadc75fae22025-02-03T01:13:19ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162023-07-015211710.1186/s40463-023-00653-6Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgeryChung-Wei Lin0Pei-Wen Lin1Li-Wen Chiu2Han-Tan Chai3Chun-Tuan Chang4Michael Friedman5Anna M. Salapatas6Sara Rahavi-Ezabadi7Hsin-Ching Lin8Department of Education, Kaohsiung Chang Gung Memorial HospitalDivision of Glaucoma, Department of Ophthalmology, Kaohsiung Chang Gung Memorial HospitalDepartment of Education, Kaohsiung Chang Gung Memorial HospitalDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial HospitalDepartment of Business Management, Institute of Healthcare Management, Institute of Biomedical Sciences, National Sun Yat-Sen UniversityDepartment of Otolaryngology, Division of Sleep Surgery, Rush University Medical CenterDepartment of Otolaryngology, Advanced Center for Specialty Care, Advocate Illinois Masonic Medical CenterOtorhinolaryngology Head and Neck Surgery Department, Otorhinolaryngology Research Center, Children’s Medical Center, Tehran University of Medical SciencesCollege of Medicine, Chang Gung UniversityAbstract Background Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR and PLR following obstructive sleep apnea (OSA) treatment were under studied and thus should be investigated. This study aimed to evaluate the changes of inflammatory biomarkers including NLR and PLR in severe OSA patients after surgical interventions of the upper airway, and their relationships with improvements in polysomnographic (PSG) parameters. Methods This retrospective cohort study included 563 consecutive severe OSA patients at a tertiary academic medical center who received OSA surgery, as well as underwent pre- and post-operative polysomnographic (PSG) examinations and blood tests. The changes of major PSG estimates, NLR, and PLR before and at least 3 months after OSA surgery were analyzed using paired t-tests with subgroup analyses. Pearson’s correlations were performed to discover which PSG parameter contributed to the improvement of the values. Results After OSA surgery, the major PSG estimates, NLR and PLR dropped significantly in the overall population. In those with a higher preoperative NLR (pre-operative NLR≧3) and PLR (pre-operative PLR≧150), the mean (SD) difference of NLR (− 0.8 [1.6], 95% CI − 1.5 to − 0.2) and PLR (− 41.6 [40], 95% CI − 52.8 to − 30.5) were even more substantial. The changes of the “apnea, longest (r = 0.298, P = .037)” and “hypopnea, longest (r = 0.321, P = .026)” were found significantly related to the improvement of PLR. Conclusion NLR and PLR did significantly drop in severe OSA patients following OSA surgery, and this could be related to the alterations of sleep indices. The findings could possess clinical importance for severe OSA patients after OSA surgeries in reducing possible OSA-associated cardiovascular comorbidities.https://doi.org/10.1186/s40463-023-00653-6SnoringObstructive sleep apneaInflammatory biomarkerCoronary artery diseaseStroke |
| spellingShingle | Chung-Wei Lin Pei-Wen Lin Li-Wen Chiu Han-Tan Chai Chun-Tuan Chang Michael Friedman Anna M. Salapatas Sara Rahavi-Ezabadi Hsin-Ching Lin Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery Journal of Otolaryngology - Head and Neck Surgery Snoring Obstructive sleep apnea Inflammatory biomarker Coronary artery disease Stroke |
| title | Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery |
| title_full | Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery |
| title_fullStr | Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery |
| title_full_unstemmed | Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery |
| title_short | Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery |
| title_sort | inflammatory biomarkers of neutrophil to lymphocyte and platelet to lymphocyte ratios in 563 severe osa patients before and after surgery |
| topic | Snoring Obstructive sleep apnea Inflammatory biomarker Coronary artery disease Stroke |
| url | https://doi.org/10.1186/s40463-023-00653-6 |
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