Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis
Background. Spur cell anemia (SCA) is a cause of hemolytic anemia in patients with alcoholic liver cirrhosis. Because dyslipidemia is related to the development of spur cells, SCA was previously treated with plasmapheresis. Case Report. A 52-year-old Japanese man with SCA associated with alcoholic l...
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/9513946 |
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| author | Kenji Miki Takashi Maruki Shinsaku Imashuku |
| author_facet | Kenji Miki Takashi Maruki Shinsaku Imashuku |
| author_sort | Kenji Miki |
| collection | DOAJ |
| description | Background. Spur cell anemia (SCA) is a cause of hemolytic anemia in patients with alcoholic liver cirrhosis. Because dyslipidemia is related to the development of spur cells, SCA was previously treated with plasmapheresis. Case Report. A 52-year-old Japanese man with SCA associated with alcoholic liver cirrhosis (Child–Pugh C) underwent two rounds of plasmapheresis. Clinical features and serum lipid concentrations were compared before and after plasmapheresis. Although indirect hyperbilirubinemia and SCA persisted after plasmapheresis, reticulocyte counts significantly decreased from 22.4% to 4.5%, and Hb levels improved without red cell transfusions. Analysis of lipids showed that total and free cholesterol, HDL cholesterol, phospholipid, and apo-AI concentrations, all of which were reduced before plasmapheresis, had improved after treatment, while LDL cholesterol, lipoprotein (a), and apo-AII concentrations, which were also reduced before plasmapheresis, remained unchanged. Conclusions. Despite plasmapheresis partially ameliorating the degree of hemolysis, the persistence of SCA may have been linked with the lack of improvement in certain types of lipid metabolism. |
| format | Article |
| id | doaj-art-c456549393714edabb067074e2ff2212 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Case Reports in Hematology |
| spelling | doaj-art-c456549393714edabb067074e2ff22122025-02-03T01:12:54ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/95139469513946Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver CirrhosisKenji Miki0Takashi Maruki1Shinsaku Imashuku2Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanBackground. Spur cell anemia (SCA) is a cause of hemolytic anemia in patients with alcoholic liver cirrhosis. Because dyslipidemia is related to the development of spur cells, SCA was previously treated with plasmapheresis. Case Report. A 52-year-old Japanese man with SCA associated with alcoholic liver cirrhosis (Child–Pugh C) underwent two rounds of plasmapheresis. Clinical features and serum lipid concentrations were compared before and after plasmapheresis. Although indirect hyperbilirubinemia and SCA persisted after plasmapheresis, reticulocyte counts significantly decreased from 22.4% to 4.5%, and Hb levels improved without red cell transfusions. Analysis of lipids showed that total and free cholesterol, HDL cholesterol, phospholipid, and apo-AI concentrations, all of which were reduced before plasmapheresis, had improved after treatment, while LDL cholesterol, lipoprotein (a), and apo-AII concentrations, which were also reduced before plasmapheresis, remained unchanged. Conclusions. Despite plasmapheresis partially ameliorating the degree of hemolysis, the persistence of SCA may have been linked with the lack of improvement in certain types of lipid metabolism.http://dx.doi.org/10.1155/2018/9513946 |
| spellingShingle | Kenji Miki Takashi Maruki Shinsaku Imashuku Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis Case Reports in Hematology |
| title | Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis |
| title_full | Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis |
| title_fullStr | Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis |
| title_full_unstemmed | Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis |
| title_short | Plasmapheresis for Spur Cell Anemia in a Patient with Alcoholic Liver Cirrhosis |
| title_sort | plasmapheresis for spur cell anemia in a patient with alcoholic liver cirrhosis |
| url | http://dx.doi.org/10.1155/2018/9513946 |
| work_keys_str_mv | AT kenjimiki plasmapheresisforspurcellanemiainapatientwithalcoholiclivercirrhosis AT takashimaruki plasmapheresisforspurcellanemiainapatientwithalcoholiclivercirrhosis AT shinsakuimashuku plasmapheresisforspurcellanemiainapatientwithalcoholiclivercirrhosis |