Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production

Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production

IntroductionLung cancer is considered to be the world’s leading malignancy in morbidity and mortality, and despite great efforts to treat it no effective treatment has yet been found. Isoliensinine is a natural small-molecule drug with potent anti-tumor activity in several cancer cell lines. Here, w...

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Bibliographic Details
Main Authors: Cheng Chen, Chenying Shu, Dan Shen, Zhaowei Yan, Zeyi Liu, Jian-An Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Isoliensinine
lung adenocarcinoma
APEX1
reactive oxygen species
natural compound
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555802/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1555802/full

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