Mitochondrial Disorder Aggravated by Metoprolol
Beta-adrenergic blocking agents or beta-blockers are a class of medications used to treat cardiac arrhythmias and systemic hypertension. In therapeutic dosages, they have known adverse outcomes that can include muscular fatigue and cramping, dizziness, and dyspnea. In patients with mitochondrial dis...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2016/7869174 |
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| _version_ | 1832555810206515200 |
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| author | Cheryl Samuels Mary Kay Koenig Mariana Hernandez Aravind Yadav Ricardo A. Mosquera |
| author_facet | Cheryl Samuels Mary Kay Koenig Mariana Hernandez Aravind Yadav Ricardo A. Mosquera |
| author_sort | Cheryl Samuels |
| collection | DOAJ |
| description | Beta-adrenergic blocking agents or beta-blockers are a class of medications used to treat cardiac arrhythmias and systemic hypertension. In therapeutic dosages, they have known adverse outcomes that can include muscular fatigue and cramping, dizziness, and dyspnea. In patients with mitochondrial disease, these effects can be amplified. Previous case reports have been published in the adult population; however, their impact in pediatric patients has not been reported. We describe a pediatric patient with a mitochondrial disorder who developed respiratory distress after metoprolol was prescribed for hypertension. As the patient improved with discontinuation of medication and no alternative etiology was found for symptoms, we surmise that administration of metoprolol aggravated his mitochondrial dysfunction, thus worsening underlying chest wall weakness. |
| format | Article |
| id | doaj-art-c43367c27fae497699e8c1874e8798aa |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-c43367c27fae497699e8c1874e8798aa2025-02-03T05:47:09ZengWileyCase Reports in Pediatrics2090-68032090-68112016-01-01201610.1155/2016/78691747869174Mitochondrial Disorder Aggravated by MetoprololCheryl Samuels0Mary Kay Koenig1Mariana Hernandez2Aravind Yadav3Ricardo A. Mosquera4Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USADepartment of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USADepartment of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USADepartment of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USADepartment of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USABeta-adrenergic blocking agents or beta-blockers are a class of medications used to treat cardiac arrhythmias and systemic hypertension. In therapeutic dosages, they have known adverse outcomes that can include muscular fatigue and cramping, dizziness, and dyspnea. In patients with mitochondrial disease, these effects can be amplified. Previous case reports have been published in the adult population; however, their impact in pediatric patients has not been reported. We describe a pediatric patient with a mitochondrial disorder who developed respiratory distress after metoprolol was prescribed for hypertension. As the patient improved with discontinuation of medication and no alternative etiology was found for symptoms, we surmise that administration of metoprolol aggravated his mitochondrial dysfunction, thus worsening underlying chest wall weakness.http://dx.doi.org/10.1155/2016/7869174 |
| spellingShingle | Cheryl Samuels Mary Kay Koenig Mariana Hernandez Aravind Yadav Ricardo A. Mosquera Mitochondrial Disorder Aggravated by Metoprolol Case Reports in Pediatrics |
| title | Mitochondrial Disorder Aggravated by Metoprolol |
| title_full | Mitochondrial Disorder Aggravated by Metoprolol |
| title_fullStr | Mitochondrial Disorder Aggravated by Metoprolol |
| title_full_unstemmed | Mitochondrial Disorder Aggravated by Metoprolol |
| title_short | Mitochondrial Disorder Aggravated by Metoprolol |
| title_sort | mitochondrial disorder aggravated by metoprolol |
| url | http://dx.doi.org/10.1155/2016/7869174 |
| work_keys_str_mv | AT cherylsamuels mitochondrialdisorderaggravatedbymetoprolol AT marykaykoenig mitochondrialdisorderaggravatedbymetoprolol AT marianahernandez mitochondrialdisorderaggravatedbymetoprolol AT aravindyadav mitochondrialdisorderaggravatedbymetoprolol AT ricardoamosquera mitochondrialdisorderaggravatedbymetoprolol |