The Role of Purinergic Mechanisms in the Excitability of Trigeminal Afferents of Rats with Prenatal Hyperhomocysteinemia

The Role of Purinergic Mechanisms in the Excitability of Trigeminal Afferents of Rats with Prenatal Hyperhomocysteinemia

Elevated levels of homocysteine in the blood plasma (hyperhomocysteinemia, HHCY) positively correlate with migraine symptoms in patients. Experimental studies show a higher sensitivity of rats with prenatal HHCY (pHHCY) to migraine symptoms like allodynia, photophobia, anxiety, and a higher excitabi...

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Main Authors: Elizaveta Ermakova, Svetlana Svitko, Alsu Kabirova, Egor Nevsky, Olga Yakovleva, Karina Gilizhdinova, Kseniia Shaidullova, Anton Hermann, Guzel Sitdikova
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
migraine
homocysteine
trigeminal ganglion (TG) cells
meningeal afferents
mast cells
calcitonin gene-related peptide (CGRP)
Online Access:https://www.mdpi.com/2218-273X/15/3/419
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