Single-cell spatial transcriptomics unravels cell states and ecosystems associated with clinical response to immunotherapy

Single-cell spatial transcriptomics unravels cell states and ecosystems associated with clinical response to immunotherapy

Background The tumor microenvironment (TME) is a complex and dynamic ecosystem that is known to influence responses to immunotherapy. We leveraged single-cell spatial transcriptomics to systematically dissect the intricate complexity of the TME, in particular the cellular heterogeneity and spatial i...

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Bibliographic Details
Main Authors: Sjoerd H van der Burg, Ziena Abdulrahman, Mariette I E van Poelgeest, Roderick C Slieker, Marij J P Welters, Daniel McGuire
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/3/e011308.full
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