Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin
Following severe tissue injury, patients are exposed to various danger- and microbe-associated molecular patterns, which provoke a strong activation of the neutrophil defense system. Neutrophils trigger and modulate the initial posttraumatic inflammatory response and contribute critically to subsequ...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8173983 |
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| author | A. Kovtun D. A. C. Messerer K. Scharffetter-Kochanek M. Huber-Lang A. Ignatius |
| author_facet | A. Kovtun D. A. C. Messerer K. Scharffetter-Kochanek M. Huber-Lang A. Ignatius |
| author_sort | A. Kovtun |
| collection | DOAJ |
| description | Following severe tissue injury, patients are exposed to various danger- and microbe-associated molecular patterns, which provoke a strong activation of the neutrophil defense system. Neutrophils trigger and modulate the initial posttraumatic inflammatory response and contribute critically to subsequent repair processes. However, severe trauma can affect central neutrophil functions, including circulation half-life, chemokinesis, phagocytosis, cytokine release, and respiratory burst. Alterations in neutrophil biology may contribute to trauma-associated complications, including immune suppression, sepsis, multiorgan dysfunction, and disturbed tissue regeneration. Furthermore, there is evidence that neutrophil actions depend on the quality of the initial stimulus, including trauma localization and severity, the micromilieu in the affected tissue, and the patient’s overall inflammatory status. In the present review, we describe the effects of severe trauma on the neutrophil phenotype and dysfunction and the consequences for tissue repair. We particularly concentrate on the role of neutrophils in wound healing, lung injury, and bone fractures, because these are the most frequently affected tissues in severely injured patients. |
| format | Article |
| id | doaj-art-c3fa3e58202f4642b64a6d5b371dba55 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c3fa3e58202f4642b64a6d5b371dba552025-02-03T01:23:26ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/81739838173983Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same CoinA. Kovtun0D. A. C. Messerer1K. Scharffetter-Kochanek2M. Huber-Lang3A. Ignatius4Institute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, University of Ulm, 89081 Ulm, GermanyInstitute of Clinical and Experimental Trauma Immunology (ITI), Trauma Research Center Ulm, University of Ulm, 89081 Ulm, GermanyDepartment of Dermatology and Allergic Diseases, Trauma Research Center Ulm, University of Ulm, 89081 Ulm, GermanyInstitute of Clinical and Experimental Trauma Immunology (ITI), Trauma Research Center Ulm, University of Ulm, 89081 Ulm, GermanyInstitute of Orthopedic Research and Biomechanics, Trauma Research Center Ulm, University of Ulm, 89081 Ulm, GermanyFollowing severe tissue injury, patients are exposed to various danger- and microbe-associated molecular patterns, which provoke a strong activation of the neutrophil defense system. Neutrophils trigger and modulate the initial posttraumatic inflammatory response and contribute critically to subsequent repair processes. However, severe trauma can affect central neutrophil functions, including circulation half-life, chemokinesis, phagocytosis, cytokine release, and respiratory burst. Alterations in neutrophil biology may contribute to trauma-associated complications, including immune suppression, sepsis, multiorgan dysfunction, and disturbed tissue regeneration. Furthermore, there is evidence that neutrophil actions depend on the quality of the initial stimulus, including trauma localization and severity, the micromilieu in the affected tissue, and the patient’s overall inflammatory status. In the present review, we describe the effects of severe trauma on the neutrophil phenotype and dysfunction and the consequences for tissue repair. We particularly concentrate on the role of neutrophils in wound healing, lung injury, and bone fractures, because these are the most frequently affected tissues in severely injured patients.http://dx.doi.org/10.1155/2018/8173983 |
| spellingShingle | A. Kovtun D. A. C. Messerer K. Scharffetter-Kochanek M. Huber-Lang A. Ignatius Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin Journal of Immunology Research |
| title | Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin |
| title_full | Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin |
| title_fullStr | Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin |
| title_full_unstemmed | Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin |
| title_short | Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin |
| title_sort | neutrophils in tissue trauma of the skin bone and lung two sides of the same coin |
| url | http://dx.doi.org/10.1155/2018/8173983 |
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