Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China
BackgroundThe relationship between abnormal renal function and serum uric acid levels in patients with acute ischemic stroke (AIS) remains insufficiently explored. Although uric acid is associated with cardiovascular and cerebrovascular risk, the specific link between normalized serum uric acid (SUA...
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Frontiers Media S.A.
2025-02-01
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| author | Zhongzhong Liu Zhongzhong Liu Zhongzhong Liu Dandan Zhang Dandan Zhang Lingxia Zeng Weiyan Guo Qingli Lu Qingli Lu Zhen Lei Yunlong Hao Pei Liu Pei Liu Tong Liu Tong Liu Linna Peng Linna Peng Qiaoqiao Chang Qiaoqiao Chang Mi Zhang Mi Zhang Xuemei Lin Xuemei Lin Fang Wang Fang Wang Songdi Wu Songdi Wu Songdi Wu Songdi Wu |
| author_facet | Zhongzhong Liu Zhongzhong Liu Zhongzhong Liu Dandan Zhang Dandan Zhang Lingxia Zeng Weiyan Guo Qingli Lu Qingli Lu Zhen Lei Yunlong Hao Pei Liu Pei Liu Tong Liu Tong Liu Linna Peng Linna Peng Qiaoqiao Chang Qiaoqiao Chang Mi Zhang Mi Zhang Xuemei Lin Xuemei Lin Fang Wang Fang Wang Songdi Wu Songdi Wu Songdi Wu Songdi Wu |
| author_sort | Zhongzhong Liu |
| collection | DOAJ |
| description | BackgroundThe relationship between abnormal renal function and serum uric acid levels in patients with acute ischemic stroke (AIS) remains insufficiently explored. Although uric acid is associated with cardiovascular and cerebrovascular risk, the specific link between normalized serum uric acid (SUA/SCr) and stroke recurrence in patients with impaired renal function has not been well studied. This study aims to fill this gap by investigating the association between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function.MethodsThis study utilized the ratio of serum uric acid (SUA) to serum creatinine (SCr) to represent SUA levels normalized for renal function. Abnormal Renal function was defined by the estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m2. Multivariable Cox regression, curve fitting, and stratified analyses were employed to assess the relationship between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function, considering SUA/SCr as both a continuous variable and in quartiles (Q1–Q4).ResultsOf 1,932 enrolled patients (65.3% male; mean age 66.7 ± 11.3 years), each unit of increase in SUA/SCr was associated with a 17% decrease in 1-year stroke recurrence (HR = 0.83, 95% CI 0.73 to 0.96, P = 0.009). Compared to Q1, the Q2 and Q4 groups showed significantly reduced risk in 1-year stroke recurrence (Q2: HR = 0.46, 95% CI 0.27 to 0.79, P = 0.005; Q4: HR = 0.47, 95% CI 0.27 to 0.81, P = 0.007), with a significant trend across all quartiles (P = 0.01 for trend tests). Curve fitting revealed a negative but non-linear correlation. Subgroup analyses showed that in patients with eGFR < 60 ml/min/1.73 m2, Q4 had significantly lower 1-year stroke recurrence risk than Q1 (HR = 0.19, 95% CI 0.04 to 0.86, P = 0.031).ConclusionLow SUA/SCr independently predicts 1-year stroke recurrence in patients with AIS and abnormal renal function, particularly in those with eGFR < 60 mL/min/1.73 m2. |
| format | Article |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-c3e94780c08046f59e6cd536d0d9bdb02025-02-04T05:28:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.14967911496791Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of ChinaZhongzhong Liu0Zhongzhong Liu1Zhongzhong Liu2Dandan Zhang3Dandan Zhang4Lingxia Zeng5Weiyan Guo6Qingli Lu7Qingli Lu8Zhen Lei9Yunlong Hao10Pei Liu11Pei Liu12Tong Liu13Tong Liu14Linna Peng15Linna Peng16Qiaoqiao Chang17Qiaoqiao Chang18Mi Zhang19Mi Zhang20Xuemei Lin21Xuemei Lin22Fang Wang23Fang Wang24Songdi Wu25Songdi Wu26Songdi Wu27Songdi Wu28Department of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health of Xi'an Jiaotong University Health Science Center, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health of Xi'an Jiaotong University Health Science Center, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaCollege of Life Science, Northwest University, Xi'an, ChinaSchool of Medicine, Xizang Minzu University, Xianyang, Shaanxi, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaDepartment of Neurology, Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, ChinaXi'an Key Laboratory for Innovation and Translation of Neuroimmunological Diseases, Xi'an, ChinaCollege of Life Science, Northwest University, Xi'an, ChinaSchool of Medicine, Xizang Minzu University, Xianyang, Shaanxi, ChinaBackgroundThe relationship between abnormal renal function and serum uric acid levels in patients with acute ischemic stroke (AIS) remains insufficiently explored. Although uric acid is associated with cardiovascular and cerebrovascular risk, the specific link between normalized serum uric acid (SUA/SCr) and stroke recurrence in patients with impaired renal function has not been well studied. This study aims to fill this gap by investigating the association between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function.MethodsThis study utilized the ratio of serum uric acid (SUA) to serum creatinine (SCr) to represent SUA levels normalized for renal function. Abnormal Renal function was defined by the estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m2. Multivariable Cox regression, curve fitting, and stratified analyses were employed to assess the relationship between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function, considering SUA/SCr as both a continuous variable and in quartiles (Q1–Q4).ResultsOf 1,932 enrolled patients (65.3% male; mean age 66.7 ± 11.3 years), each unit of increase in SUA/SCr was associated with a 17% decrease in 1-year stroke recurrence (HR = 0.83, 95% CI 0.73 to 0.96, P = 0.009). Compared to Q1, the Q2 and Q4 groups showed significantly reduced risk in 1-year stroke recurrence (Q2: HR = 0.46, 95% CI 0.27 to 0.79, P = 0.005; Q4: HR = 0.47, 95% CI 0.27 to 0.81, P = 0.007), with a significant trend across all quartiles (P = 0.01 for trend tests). Curve fitting revealed a negative but non-linear correlation. Subgroup analyses showed that in patients with eGFR < 60 ml/min/1.73 m2, Q4 had significantly lower 1-year stroke recurrence risk than Q1 (HR = 0.19, 95% CI 0.04 to 0.86, P = 0.031).ConclusionLow SUA/SCr independently predicts 1-year stroke recurrence in patients with AIS and abnormal renal function, particularly in those with eGFR < 60 mL/min/1.73 m2.https://www.frontiersin.org/articles/10.3389/fneur.2025.1496791/fullischemic strokerenal functionstroke recurrenceoutcomes ischemic strokeoutcomes |
| spellingShingle | Zhongzhong Liu Zhongzhong Liu Zhongzhong Liu Dandan Zhang Dandan Zhang Lingxia Zeng Weiyan Guo Qingli Lu Qingli Lu Zhen Lei Yunlong Hao Pei Liu Pei Liu Tong Liu Tong Liu Linna Peng Linna Peng Qiaoqiao Chang Qiaoqiao Chang Mi Zhang Mi Zhang Xuemei Lin Xuemei Lin Fang Wang Fang Wang Songdi Wu Songdi Wu Songdi Wu Songdi Wu Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China Frontiers in Neurology ischemic stroke renal function stroke recurrence outcomes ischemic stroke outcomes |
| title | Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China |
| title_full | Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China |
| title_fullStr | Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China |
| title_full_unstemmed | Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China |
| title_short | Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China |
| title_sort | serum uric acid creatinine ratio and 1 year stroke recurrence in patient with acute ischemic stroke and abnormal renal function results from the xi an stroke registry study of china |
| topic | ischemic stroke renal function stroke recurrence outcomes ischemic stroke outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1496791/full |
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