Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions
Osteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of cartilage, and structural changes in bone including the formation of osteophytes, causing disability and loss of function. It is also associated with systemic mediators and low-grade inflammation. Currently, ther...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/5574582 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551333573427200 |
|---|---|
| author | Rajkamal Kumavat Vijay Kumar Rajesh Malhotra Hemant Pandit Elena Jones Frederique Ponchel Sagarika Biswas |
| author_facet | Rajkamal Kumavat Vijay Kumar Rajesh Malhotra Hemant Pandit Elena Jones Frederique Ponchel Sagarika Biswas |
| author_sort | Rajkamal Kumavat |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of cartilage, and structural changes in bone including the formation of osteophytes, causing disability and loss of function. It is also associated with systemic mediators and low-grade inflammation. Currently, there is negligible/no availability of specific biomarkers that can be used to facilitate the diagnosis and treatment of OA. The most unmet clinical need is, however, related to the monitoring of disease progression over a short period that can be used in clinical trials. In this review, the value of biomarkers identified over the past decade has been highlighted. These biomarkers are associated with the synthesis and breakdown of cartilage, including collagenous and noncollagenous biomarkers, inflammatory and anti-inflammatory biomarkers, expressed in the biological fluid such as serum, synovial fluid, and urine. Broad validation of novel and clinically applicable biomarkers and their involvement in the pathways are particularly needed for early-stage diagnosis, monitoring disease progression, and severity and examining new drugs to mitigate the effects of this highly prevalent and debilitating condition. |
| format | Article |
| id | doaj-art-c3e284e8f03e40a18e2f0fd15f059751 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c3e284e8f03e40a18e2f0fd15f0597512025-02-03T06:01:48ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/55745825574582Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future DirectionsRajkamal Kumavat0Vijay Kumar1Rajesh Malhotra2Hemant Pandit3Elena Jones4Frederique Ponchel5Sagarika Biswas6Department of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Mall Road, -110007, Delhi, IndiaAll India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaAll India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaLeeds Institute of Rheumatic and Musculoskeletal Medicine, The University of Leeds, Leeds, UKLeeds Institute of Rheumatic and Musculoskeletal Medicine, The University of Leeds, Leeds, UKLeeds Institute of Rheumatic and Musculoskeletal Medicine, The University of Leeds, Leeds, UKDepartment of Integrative and Functional Biology, CSIR-Institute of Genomics & Integrative Biology, Mall Road, -110007, Delhi, IndiaOsteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of cartilage, and structural changes in bone including the formation of osteophytes, causing disability and loss of function. It is also associated with systemic mediators and low-grade inflammation. Currently, there is negligible/no availability of specific biomarkers that can be used to facilitate the diagnosis and treatment of OA. The most unmet clinical need is, however, related to the monitoring of disease progression over a short period that can be used in clinical trials. In this review, the value of biomarkers identified over the past decade has been highlighted. These biomarkers are associated with the synthesis and breakdown of cartilage, including collagenous and noncollagenous biomarkers, inflammatory and anti-inflammatory biomarkers, expressed in the biological fluid such as serum, synovial fluid, and urine. Broad validation of novel and clinically applicable biomarkers and their involvement in the pathways are particularly needed for early-stage diagnosis, monitoring disease progression, and severity and examining new drugs to mitigate the effects of this highly prevalent and debilitating condition.http://dx.doi.org/10.1155/2021/5574582 |
| spellingShingle | Rajkamal Kumavat Vijay Kumar Rajesh Malhotra Hemant Pandit Elena Jones Frederique Ponchel Sagarika Biswas Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions Mediators of Inflammation |
| title | Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions |
| title_full | Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions |
| title_fullStr | Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions |
| title_full_unstemmed | Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions |
| title_short | Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions |
| title_sort | biomarkers of joint damage in osteoarthritis current status and future directions |
| url | http://dx.doi.org/10.1155/2021/5574582 |
| work_keys_str_mv | AT rajkamalkumavat biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections AT vijaykumar biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections AT rajeshmalhotra biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections AT hemantpandit biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections AT elenajones biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections AT frederiqueponchel biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections AT sagarikabiswas biomarkersofjointdamageinosteoarthritiscurrentstatusandfuturedirections |