Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.

Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization, leading to an immature virus particle that is formed by a protein lattice based on dimeric, trimeric, and hexameric protein contacts. Among retr...

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Bibliographic Details
Main Authors: Robert A Dick, Chaoyi Xu, Dustin R Morado, Vladyslav Kravchuk, Clifton L Ricana, Terri D Lyddon, Arianna M Broad, J Ryan Feathers, Marc C Johnson, Volker M Vogt, Juan R Perilla, John A G Briggs, Florian K M Schur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Pathogens
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.ppat.1008277/2/ppat.1008277.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T070956Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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