Analysis methods for covariate-constrained cluster randomized trials with time-to-event outcomes

Analysis methods for covariate-constrained cluster randomized trials with time-to-event outcomes

Abstract Background Cluster randomized trials, which often enroll a small number of clusters, can benefit from constrained randomization, selecting a final randomization scheme from a set of known, balanced randomizations. Previous literature has addressed the suitability of adjusting the analysis f...

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Bibliographic Details
Main Authors: Amy M. Crisp, M. Elizabeth Halloran, Matt D. T. Hitchings, Ira M. Longini, Natalie E. Dean
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Medical Research Methodology
Subjects:
Clinical trial design
Cluster-randomized
Constrained randomization
Time-to-event
Permutation test
Online Access:https://doi.org/10.1186/s12874-025-02465-w
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