Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points
Background: Little is known about the impact of residential segregation on early detection, treatment, and prognosis of non-small cell lung cancer (NSCLC), a predominant type of lung cancers. Research Question: Does racialized economic segregation play a role in NSCLC treatment and outcomes and cont...
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| Format: | Article |
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Elsevier
2025-03-01
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| Series: | CHEST Pulmonary |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949789224000679 |
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| author | Pratibha Shrestha, MPH, PhD Min Lian, MD, PhD James Struthers, BA Oumarou Nabi, PhD Bayu B. Bekele, MPH, PhD Benjamin Kozower, MD Maria Baggstrom, MD Ying Liu, MD, PhD |
| author_facet | Pratibha Shrestha, MPH, PhD Min Lian, MD, PhD James Struthers, BA Oumarou Nabi, PhD Bayu B. Bekele, MPH, PhD Benjamin Kozower, MD Maria Baggstrom, MD Ying Liu, MD, PhD |
| author_sort | Pratibha Shrestha, MPH, PhD |
| collection | DOAJ |
| description | Background: Little is known about the impact of residential segregation on early detection, treatment, and prognosis of non-small cell lung cancer (NSCLC), a predominant type of lung cancers. Research Question: Does racialized economic segregation play a role in NSCLC treatment and outcomes and contribute to racial disparities? Study Design and Methods: This study included non-Hispanic White (NHW) and non-Hispanic Black (NHB) patients with NSCLC diagnosed between 2007 and 2015 and identified from the Surveillance, Epidemiology, and End Results data set. County-level racialized economic segregation was estimated by using the Index of Concentration at the Extremes (ICE). Multilevel logistic regression and multilevel Cox regression accounting for county-level clustering were used to estimate ORs for late-stage diagnosis and treatment underutilization, and hazard ratios (HRs) were used for mortality. Results: Of 203,441 patients, 85.8% were NHW, and 14.2% were NHB. Compared with patients living in the counties with the highest concentration of high-income NHW households (lowest ICE quintile), patients living in the counties with the highest concentration of low-income NHB households (highest ICE quintile) had higher risks of late-stage diagnosis (OR, 1.09; 95% CI, 1.02-1.16; Ptrend < .001), underutilization of guideline-recommended treatment (OR, 1.28; 95% CI, 1.16-1.41; Ptrend < .0001), lung cancer-specific mortality (HR, 1.10; 95% CI, 1.07-1.14; Ptrend < .0001), and overall mortality (HR, 1.12; 95% CI, 1.09-1.16; Ptrend < .0001). The association between segregation and treatment underutilization was stronger in NHW patients than in NHB patients (Pinteraction = .02). There was no significant difference in the segregation-related risk of late-stage diagnosis, lung cancer-specific mortality, or overall mortality between NHW and NHB patients. Interpretation: Living in segregated, low-income counties with predominately NHB residents has adverse impacts on early detection, treatment, and outcomes of NSCLC. However, residential segregation did not explain the excess risks of NSCLC care underutilization and mortality in NHB patients compared with NHW patients. |
| format | Article |
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| institution | OA Journals |
| issn | 2949-7892 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | CHEST Pulmonary |
| spelling | doaj-art-c3c0a3bb4cd74d49b819f6431c20a7282025-08-20T02:19:23ZengElsevierCHEST Pulmonary2949-78922025-03-013110010110.1016/j.chpulm.2024.100101Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home PointsPratibha Shrestha, MPH, PhD0Min Lian, MD, PhD1James Struthers, BA2Oumarou Nabi, PhD3Bayu B. Bekele, MPH, PhD4Benjamin Kozower, MD5Maria Baggstrom, MD6Ying Liu, MD, PhD7Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MODivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Alvin J. Siteman Cancer Center, Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MODivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MODivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MODivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MOAlvin J. Siteman Cancer Center, Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO; Department of Surgery, Washington University School of Medicine, St. Louis, MODivision of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MODivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO; Alvin J. Siteman Cancer Center, Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO; CORRESPONDENCE TO: Ying Liu, MD, PhDBackground: Little is known about the impact of residential segregation on early detection, treatment, and prognosis of non-small cell lung cancer (NSCLC), a predominant type of lung cancers. Research Question: Does racialized economic segregation play a role in NSCLC treatment and outcomes and contribute to racial disparities? Study Design and Methods: This study included non-Hispanic White (NHW) and non-Hispanic Black (NHB) patients with NSCLC diagnosed between 2007 and 2015 and identified from the Surveillance, Epidemiology, and End Results data set. County-level racialized economic segregation was estimated by using the Index of Concentration at the Extremes (ICE). Multilevel logistic regression and multilevel Cox regression accounting for county-level clustering were used to estimate ORs for late-stage diagnosis and treatment underutilization, and hazard ratios (HRs) were used for mortality. Results: Of 203,441 patients, 85.8% were NHW, and 14.2% were NHB. Compared with patients living in the counties with the highest concentration of high-income NHW households (lowest ICE quintile), patients living in the counties with the highest concentration of low-income NHB households (highest ICE quintile) had higher risks of late-stage diagnosis (OR, 1.09; 95% CI, 1.02-1.16; Ptrend < .001), underutilization of guideline-recommended treatment (OR, 1.28; 95% CI, 1.16-1.41; Ptrend < .0001), lung cancer-specific mortality (HR, 1.10; 95% CI, 1.07-1.14; Ptrend < .0001), and overall mortality (HR, 1.12; 95% CI, 1.09-1.16; Ptrend < .0001). The association between segregation and treatment underutilization was stronger in NHW patients than in NHB patients (Pinteraction = .02). There was no significant difference in the segregation-related risk of late-stage diagnosis, lung cancer-specific mortality, or overall mortality between NHW and NHB patients. Interpretation: Living in segregated, low-income counties with predominately NHB residents has adverse impacts on early detection, treatment, and outcomes of NSCLC. However, residential segregation did not explain the excess risks of NSCLC care underutilization and mortality in NHB patients compared with NHW patients.http://www.sciencedirect.com/science/article/pii/S2949789224000679lung cancerracial disparityresidential segregation |
| spellingShingle | Pratibha Shrestha, MPH, PhD Min Lian, MD, PhD James Struthers, BA Oumarou Nabi, PhD Bayu B. Bekele, MPH, PhD Benjamin Kozower, MD Maria Baggstrom, MD Ying Liu, MD, PhD Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points CHEST Pulmonary lung cancer racial disparity residential segregation |
| title | Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points |
| title_full | Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points |
| title_fullStr | Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points |
| title_full_unstemmed | Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points |
| title_short | Racialized Economic Segregation and Disparities in Non-Small Cell Lung Cancer Care and OutcomesTake-home Points |
| title_sort | racialized economic segregation and disparities in non small cell lung cancer care and outcomestake home points |
| topic | lung cancer racial disparity residential segregation |
| url | http://www.sciencedirect.com/science/article/pii/S2949789224000679 |
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