Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study
Background. WHO’s recommendation of HbA1c≥48 mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. We compared participants diagnosed b...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/587673 |
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| author | Mohsin Azam Lindsey Marwood Khalida Ismail Tyrrell Evans Sobha Sivaprasad Kirsty Winkley Stephanie Anne Amiel |
| author_facet | Mohsin Azam Lindsey Marwood Khalida Ismail Tyrrell Evans Sobha Sivaprasad Kirsty Winkley Stephanie Anne Amiel |
| author_sort | Mohsin Azam |
| collection | DOAJ |
| description | Background. WHO’s recommendation of HbA1c≥48 mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. We compared participants diagnosed before May 2012 with HbA1c<48 mmol/mol to those with diagnostic HbA1c≥48 mmol/mol. Methods. A prospective cohort study of newly diagnosed T2DM participants from 96 primary care practices, comparing demographic and biomedical variables between those with diagnostic HbA1c<48 mmol/mol or HbA1c≥48 mmol/mol at recruitment and after one year. Results. Of 1488 participants, 22.8% had diagnostic HbA1c<48 mmol/mol. They were older and more likely to be white (p<0.05). At recruitment and one year, there were no between-group differences in the prevalence of diabetic complications, except that those diagnosed with HbA1c<48 mmol/mol had more sensory neuropathy at recruitment (p=0.039) and, at one year, had new myocardial infarction (p=0.012) but less microalbuminuria (p=0.012). Conclusions. Use of HbA1c≥48 mmol/mol as the sole T2DM diagnostic criterion may miss almost a quarter of those previously diagnosed in South London yet HbA1c<48 mmol/mol may not exclude clinically important diabetes. |
| format | Article |
| id | doaj-art-c3b5be8a1c0341028a63d166a9f599a8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c3b5be8a1c0341028a63d166a9f599a82025-02-03T06:11:42ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/587673587673Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes StudyMohsin Azam0Lindsey Marwood1Khalida Ismail2Tyrrell Evans3Sobha Sivaprasad4Kirsty Winkley5Stephanie Anne Amiel6Division of Diabetes and Nutritional Sciences, King’s College London, Diabetes Research Group, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UKDepartment of Psychological Medicine, King’s College London, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UKDepartment of Psychological Medicine, King’s College London, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UKPaxton Green Group Practice, 1 Alleyn Park, London SE21 8AU, UKDepartment of Ophthalmology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9PJ, UKDepartment of Psychological Medicine, King’s College London, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UKDivision of Diabetes and Nutritional Sciences, King’s College London, Diabetes Research Group, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UKBackground. WHO’s recommendation of HbA1c≥48 mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. We compared participants diagnosed before May 2012 with HbA1c<48 mmol/mol to those with diagnostic HbA1c≥48 mmol/mol. Methods. A prospective cohort study of newly diagnosed T2DM participants from 96 primary care practices, comparing demographic and biomedical variables between those with diagnostic HbA1c<48 mmol/mol or HbA1c≥48 mmol/mol at recruitment and after one year. Results. Of 1488 participants, 22.8% had diagnostic HbA1c<48 mmol/mol. They were older and more likely to be white (p<0.05). At recruitment and one year, there were no between-group differences in the prevalence of diabetic complications, except that those diagnosed with HbA1c<48 mmol/mol had more sensory neuropathy at recruitment (p=0.039) and, at one year, had new myocardial infarction (p=0.012) but less microalbuminuria (p=0.012). Conclusions. Use of HbA1c≥48 mmol/mol as the sole T2DM diagnostic criterion may miss almost a quarter of those previously diagnosed in South London yet HbA1c<48 mmol/mol may not exclude clinically important diabetes.http://dx.doi.org/10.1155/2015/587673 |
| spellingShingle | Mohsin Azam Lindsey Marwood Khalida Ismail Tyrrell Evans Sobha Sivaprasad Kirsty Winkley Stephanie Anne Amiel Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study Journal of Diabetes Research |
| title | Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study |
| title_full | Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study |
| title_fullStr | Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study |
| title_full_unstemmed | Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study |
| title_short | Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study |
| title_sort | diabetes complications at presentation and one year by glycated haemoglobin at diagnosis in a multiethnic and diverse socioeconomic population results from the south london diabetes study |
| url | http://dx.doi.org/10.1155/2015/587673 |
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