High intensity interval training attenuate insulin resistance in diabetic rats accompanied by improvements in liver metabolism and spexin signaling

High intensity interval training attenuate insulin resistance in diabetic rats accompanied by improvements in liver metabolism and spexin signaling

Abstract Spexin (SPX), a recently identified adipokine, shows potential in enhancing insulin sensitivity, offering promising implications for metabolic health. This study aimed to investigate the effect of 8 weeks of high intensity interval training (HIIT) on insulin resistance through liver glucone...

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Bibliographic Details
Main Authors: Kayvan Khoramipour, Najmeh Sadat Hosseini, Jennifer W. Hill, Karen Khoramipour, Kimya Khoramipour, Sergio Maroto Izquierdo, Simone Lista, Mona Saheli
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
HIIT
Gluconeogenesis
Lipolysis
Lipogenesis
Spexin
Online Access:https://doi.org/10.1038/s41598-025-15432-8
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