How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies
In the course of pSS, inflammatory cell infiltration consists mainly of lymphocytes infiltrating exocrine glands, which leads to their impaired function. The characteristic feature is generalized dryness. The aim of this study was to attempt to answer the question whether it is possible to distingui...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1060421 |
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| author | Agata Sebastian Maciej Sebastian Maria Misterska-Skóra Patryk Woytala Katarzyna Jakuszko Piotr Wiland |
| author_facet | Agata Sebastian Maciej Sebastian Maria Misterska-Skóra Patryk Woytala Katarzyna Jakuszko Piotr Wiland |
| author_sort | Agata Sebastian |
| collection | DOAJ |
| description | In the course of pSS, inflammatory cell infiltration consists mainly of lymphocytes infiltrating exocrine glands, which leads to their impaired function. The characteristic feature is generalized dryness. The aim of this study was to attempt to answer the question whether it is possible to distinguish between patients with pSS and individuals with dryness caused by other pathologies without applying invasive studies. The study included 68 patients with pSS and 43 healthy controls with dryness. FS ≥ 1 was observed in 90% of patients with pSS (with or without dryness), and only in 23% of the control group (only with xerostomia). In the pSS group, anaemia (p=0.0085), lymphocytopenia (p=0.0006), elevated ERS (p=0.001), higher RF titer, and ANA antibodies were noted. Configuration of anti-SSA + SSB + Ro52 antibodies was characteristic for the pSS group. Considering the clinical symptoms, statistically significant differences were noted between pSS patients and the control group in frequency (p=0.02) and severity (p=0.042) of fatigue, lymphadenopathy, major salivary gland involvement, and photosensitivity to UV light. In conclusion, invasive methods are pivotal in pSS diagnosis in this salivary gland biopsy. Chronic fatigue syndrome is more common in pSS patients and can be subjective distinguishing factor in the group of people with dryness. |
| format | Article |
| id | doaj-art-c39ee6e64fb940d3b264ae7c0f3074a1 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c39ee6e64fb940d3b264ae7c0f3074a12025-02-03T01:20:26ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/10604211060421How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic StudiesAgata Sebastian0Maciej Sebastian1Maria Misterska-Skóra2Patryk Woytala3Katarzyna Jakuszko4Piotr Wiland5Department of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Minimally Invasive Surgery and Proctology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandIn the course of pSS, inflammatory cell infiltration consists mainly of lymphocytes infiltrating exocrine glands, which leads to their impaired function. The characteristic feature is generalized dryness. The aim of this study was to attempt to answer the question whether it is possible to distinguish between patients with pSS and individuals with dryness caused by other pathologies without applying invasive studies. The study included 68 patients with pSS and 43 healthy controls with dryness. FS ≥ 1 was observed in 90% of patients with pSS (with or without dryness), and only in 23% of the control group (only with xerostomia). In the pSS group, anaemia (p=0.0085), lymphocytopenia (p=0.0006), elevated ERS (p=0.001), higher RF titer, and ANA antibodies were noted. Configuration of anti-SSA + SSB + Ro52 antibodies was characteristic for the pSS group. Considering the clinical symptoms, statistically significant differences were noted between pSS patients and the control group in frequency (p=0.02) and severity (p=0.042) of fatigue, lymphadenopathy, major salivary gland involvement, and photosensitivity to UV light. In conclusion, invasive methods are pivotal in pSS diagnosis in this salivary gland biopsy. Chronic fatigue syndrome is more common in pSS patients and can be subjective distinguishing factor in the group of people with dryness.http://dx.doi.org/10.1155/2018/1060421 |
| spellingShingle | Agata Sebastian Maciej Sebastian Maria Misterska-Skóra Patryk Woytala Katarzyna Jakuszko Piotr Wiland How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies Journal of Immunology Research |
| title | How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies |
| title_full | How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies |
| title_fullStr | How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies |
| title_full_unstemmed | How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies |
| title_short | How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies |
| title_sort | how to distinguish patients with pss among individuals with dryness without invasive diagnostic studies |
| url | http://dx.doi.org/10.1155/2018/1060421 |
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