Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study
Objectives. The present study is aimed at evaluating the diagnostic value of combining shear wave elastography (SWE) parameters and the thyroid imaging reporting and data system (TIRADS) for differentiating between benign and malignant thyroid nodules. Methods. Patients who underwent conventional ul...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/4923050 |
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| author | Jing Hang Fan Li Xiao-hui Qiao Xin-hua Ye Ao Li Lian-fang Du |
| author_facet | Jing Hang Fan Li Xiao-hui Qiao Xin-hua Ye Ao Li Lian-fang Du |
| author_sort | Jing Hang |
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| description | Objectives. The present study is aimed at evaluating the diagnostic value of combining shear wave elastography (SWE) parameters and the thyroid imaging reporting and data system (TIRADS) for differentiating between benign and malignant thyroid nodules. Methods. Patients who underwent conventional ultrasonography (US) and SWE before surgery were enrolled in the current study. Each nodule was given a TIRADS risk score. The effectiveness of the SWE parameters was assessed by odds ratios (ORs). The SWE scoring risk stratification was proposed beyond 95% probability, and the desired values were obtained according to the log-normal distribution. The area under the receiver-operating characteristic (AUC) was used to compare the diagnostic performance between TIRADS-alone and TIRADS + SWE. Results. A total of 262 patients with 298 thyroid nodules were enrolled in our study. The pathological analyses were conducted on 121 benign and 177 malignant nodules. The AUC values for TIRADS-alone and TIRADS + SWE were 0.896 (accuracy 83.2%) and 0.917 (accuracy 84.2%), respectively. However, the TIRADS + SWE scores showed a higher specificity (88.4%) and positive predictive value (91.2%) as compared with the TIRADS-alone of 73.6% and 83.2%, respectively. Conclusions. Combining SWE and TIRADS improves the specificity of TIRADS-alone in differentiating between benign and malignant thyroid nodules. |
| format | Article |
| id | doaj-art-c38d6976161e4e65bc1fea1a8d413229 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c38d6976161e4e65bc1fea1a8d4132292025-02-03T01:11:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/49230504923050Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective StudyJing Hang0Fan Li1Xiao-hui Qiao2Xin-hua Ye3Ao Li4Lian-fang Du5Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, ChinaDepartment of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, ChinaObjectives. The present study is aimed at evaluating the diagnostic value of combining shear wave elastography (SWE) parameters and the thyroid imaging reporting and data system (TIRADS) for differentiating between benign and malignant thyroid nodules. Methods. Patients who underwent conventional ultrasonography (US) and SWE before surgery were enrolled in the current study. Each nodule was given a TIRADS risk score. The effectiveness of the SWE parameters was assessed by odds ratios (ORs). The SWE scoring risk stratification was proposed beyond 95% probability, and the desired values were obtained according to the log-normal distribution. The area under the receiver-operating characteristic (AUC) was used to compare the diagnostic performance between TIRADS-alone and TIRADS + SWE. Results. A total of 262 patients with 298 thyroid nodules were enrolled in our study. The pathological analyses were conducted on 121 benign and 177 malignant nodules. The AUC values for TIRADS-alone and TIRADS + SWE were 0.896 (accuracy 83.2%) and 0.917 (accuracy 84.2%), respectively. However, the TIRADS + SWE scores showed a higher specificity (88.4%) and positive predictive value (91.2%) as compared with the TIRADS-alone of 73.6% and 83.2%, respectively. Conclusions. Combining SWE and TIRADS improves the specificity of TIRADS-alone in differentiating between benign and malignant thyroid nodules.http://dx.doi.org/10.1155/2018/4923050 |
| spellingShingle | Jing Hang Fan Li Xiao-hui Qiao Xin-hua Ye Ao Li Lian-fang Du Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study International Journal of Endocrinology |
| title | Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study |
| title_full | Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study |
| title_fullStr | Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study |
| title_full_unstemmed | Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study |
| title_short | Combination of Maximum Shear Wave Elasticity Modulus and TIRADS Improves the Diagnostic Specificity in Characterizing Thyroid Nodules: A Retrospective Study |
| title_sort | combination of maximum shear wave elasticity modulus and tirads improves the diagnostic specificity in characterizing thyroid nodules a retrospective study |
| url | http://dx.doi.org/10.1155/2018/4923050 |
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