Integrating transcriptomic data with a novel drug efficacy prediction model for TCM active compound discovery

Integrating transcriptomic data with a novel drug efficacy prediction model for TCM active compound discovery

Abstract Identifying the active natural compounds remains a challenge for drug discovery, and new algorithms need to be developed to predict active ingredients from complex natural products. Here, we proposed Meta-DEP, a Meta-paths-based Drug Efficacy Prediction based on drug-protein-disease heterog...

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Bibliographic Details
Main Authors: Yingcan Li, Yu Shen, Yezi Cai, Yulin zhang, Jiahui Gao, Lei Huang, Weinuo Si, Kai Zhou, Shan Gao, Qichao Luo
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Drug efficacy prediction
Drug-protein-disease network
Disease transcriptomic data
Deep learning
Traditional Chinese medicine
Online Access:https://doi.org/10.1038/s41598-024-82498-1
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