circVEGFA inhibits apoptosis in porcine ovarian granulosa cells by binding to miR-21-3p and up-regulating TMX4 expression

circVEGFA inhibits apoptosis in porcine ovarian granulosa cells by binding to miR-21-3p and up-regulating TMX4 expression

Abstract Background Follicular atresia is a major determinant of ovarian failure in multiparous sows. Non-coding RNAs (ncRNAs) play an important role in the regulatory mechanisms controlling apoptosis within ovarian granulosa cells (GCs). Methods The circular structure of circVEGFA was validated by...

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Bibliographic Details
Main Authors: Xinxin Qin, Jinbi Zhang, Chao Yin, Fan Li, Wenjie Li, Xiaolong Cheng, Xing Du, Qifa Li, Zengxiang Pan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Ovarian Research
Subjects:
Follicular atresia
Granulosa cell apoptosis
circRNA
miRNA
TMX4
Online Access:https://doi.org/10.1186/s13048-025-01738-8
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