New strategies to enhance the efficiency and precision of drug discovery

New strategies to enhance the efficiency and precision of drug discovery

Drug discovery plays a crucial role in medicinal chemistry, serving as the cornerstone for developing new treatments to address a wide range of diseases. This review emphasizes the significance of advanced strategies, such as Click Chemistry, Targeted Protein Degradation (TPD), DNA-Encoded Libraries...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qi An, Liang Huang, Chuan Wang, Dongmei Wang, Yalan Tu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Pharmacology
Subjects:	drug discovery click chemistry targeted protein degradation (TPD) DNA-encoded libraries (DELs) computer-aided drug design (CADD)
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1550158/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Sequence Analysis of Hypothetical Proteins from 26695 to Identify Potential Virulence Factors
by: Ahmad Abu Turab Naqvi, et al.
Published: (2016-09-01)

FingerDTA: A Fingerprint-Embedding Framework for Drug-Target Binding Affinity Prediction
by: Xuekai Zhu, et al.
Published: (2023-03-01)

Caution when using network partners for target identification in drug discovery
by: Dandan Tan, et al.
Published: (2025-04-01)

Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors
by: George Nicolae Daniel Ion, et al.
Published: (2024-12-01)

Barlow Twins deep neural network for advanced 1D drug–target interaction prediction
by: Maximilian G. Schuh, et al.
Published: (2025-02-01)

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment
by: Madison Ambrose, et al.
Published: (2025-01-01)

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
by: Francisco Javier Hermoso-Pinilla, et al.
Published: (2024-02-01)

A review of drug knowledge discovery using BioNLP and tensor or matrix decomposition
by: Mina Gachloo, et al.
Published: (2019-06-01)

Photoresponsive Cellulose Nanocrystals
by: Dimitris S Argyropoulos, et al.
Published: (2011-07-01)

Linking machine learning and biophysical structural features in drug discovery
by: Armin Ahmadi, et al.
Published: (2025-01-01)

Exploring Fragment Adding Strategies to Enhance Molecule Pretraining in AI-Driven Drug Discovery
by: Zhaoxu Meng, et al.
Published: (2024-09-01)

Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery
by: Leonel Pereira, et al.
Published: (2023-12-01)

Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA
by: Dejeu, Jérôme, et al.
Published: (2023-10-01)

Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
by: Fatih Ciftci, et al.
Published: (2025-01-01)

Structural bioinformatics for rational drug design
by: Soroush Mozaffari, et al.
Published: (2025-01-01)

Potential drug targets for asthma identified through mendelian randomization analysis
by: Xingxuan Chen, et al.
Published: (2025-01-01)

A split intein and split luciferase-coupled system for detecting protein-protein interactions
by: Zhong Yao, et al.
Published: (2024-12-01)

Effect of Glycoconjugation on Cytotoxicity and Selectivity of 8-Aminoquinoline Derivatives Compared to 8-Hydroxyquinoline
by: Gabriela Pastuch-Gawołek, et al.
Published: (2025-01-01)

Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation
by: Dale O. Starkie, et al.
Published: (2024-12-01)

A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs
by: Lejing Qu, et al.
Published: (2025-01-01)

InceptionDTA: Predicting drug-target binding affinity with biological context features and inception networks
by: Mahmood Kalemati, et al.
Published: (2025-02-01)

Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows
by: Caitlin Fawcett, et al.
Published: (2024-12-01)

Improving drug repositioning with negative data labeling using large language models
by: Milan Picard, et al.
Published: (2025-02-01)

Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria
by: Eve T. Beauchemin, et al.
Published: (2025-01-01)

Predicting drug and target interaction with dilated reparameterize convolution
by: Moping Deng, et al.
Published: (2025-01-01)

Proteomic Characterization of Liver Cancer Cells Treated with Clinical Targeted Drugs for Hepatocellular Carcinoma
by: Hezhou Long, et al.
Published: (2025-01-01)

Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine
by: Izadiyan Z, et al.
Published: (2025-01-01)

Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects
by: Renxin Zhang, et al.
Published: (2025-01-01)

Synthesis and Characterization of Cross-linkable Viologen Derivatives
by: Şölen Ayaşlıgil, et al.
Published: (2023-09-01)

Synthesis of an Azido-Substituted 8-Membered Ring Laddersiloxane and Its Application in Catalysis
by: Yujia Liu, et al.
Published: (2025-01-01)

Editorial: Ovarian cancer targeted medication: PARP inhibitors, anti-angiogenic drugs, immunotherapy, and more, volume II
by: Zhi-Bin Wang, et al.
Published: (2025-02-01)

Development, opportunities, and challenges of siRNA nucleic acid drugs
by: Bowen Xiao, et al.
Published: (2025-03-01)

Recent approaches in the drug research and development of novel antimalarial drugs with new targets
by: Chinnappanna Naveen Kumar Reddy, et al.
Published: (2023-03-01)

MCF-DTI: Multi-Scale Convolutional Local–Global Feature Fusion for Drug–Target Interaction Prediction
by: Jihong Wang, et al.
Published: (2025-01-01)

“Reports of My Death Are Greatly Exaggerated”: Findings from the TEI in Libraries Survey
by: Michelle Dalmau, et al.
Published: (2015-10-01)

Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery
by: Adila Nazli, et al.
Published: (2025-01-01)

Professional development and teaching quality: Evidence from Indonesian teachers
by: Mohamad-Arief Rafsanjani, et al.
Published: (2024-07-01)

Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study
by: Min Liu, et al.
Published: (2025-01-01)

Peptide hydrogel-drug conjugates for tailored disease treatmentGuidelines to assemble peptide-based hydrogel-drug conjugates, referenced with a selection of relevant publications.
by: Thibault Cauwenbergh, et al.
Published: (2025-04-01)

Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor
by: Junying Wang, et al.
Published: (2025-01-01)