Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis

Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis

Abstract Background Microglia are essential in mediating responses to nerve injury, with neuroinflammation and engulfment of interneuron inhibitory synapses driving heightened neuronal excitability and pain hypersensitivity. Spi1 is the main regulator of microglial homeostasis in the central nervous...

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Bibliographic Details
Main Authors: Yin Xu, Xinli Liu, Hui Chen, Yun Zhao, Yubai Zhao, Yu Xie, Jiahui Pang, Hui Zeng, Yanyan Zeng, Weiwei Peng, Manxu Zheng, Wen Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:The Journal of Headache and Pain
Subjects:
Neuropathic pain
Microglia
Neuroinflammation
Phagocytosis
Spi1
Clec7a
Online Access:https://doi.org/10.1186/s10194-025-02089-x
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