Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental Colitis
The aim of the present study was to evaluate the effects of N-acetylcysteine (NAC) and L-carnitine (LCAR) supplementations on polymorphonuclear leukocytes myeloperoxidase (MPO) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde (MDA) in acetic acid (AA)-induced ulcerative colitis...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.390 |
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| _version_ | 1832559444597145600 |
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| author | Ergul Belge Kurutas Ali Cetinkaya Ertan Bulbuloglu Bulent Kantarceken |
| author_facet | Ergul Belge Kurutas Ali Cetinkaya Ertan Bulbuloglu Bulent Kantarceken |
| author_sort | Ergul Belge Kurutas |
| collection | DOAJ |
| description | The aim of the present study was to evaluate the effects of
N-acetylcysteine (NAC) and L-carnitine (LCAR) supplementations on
polymorphonuclear leukocytes myeloperoxidase (MPO) and
Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde
(MDA) in acetic acid (AA)-induced ulcerative colitis model. The
mean polymorphonuclear leukocyte MPO and Cu/Zn-SOD activity was
significantly higher in the colitis group than in the control
group. Both NAC and LCAR pretreatment markedly decreased MPO and
Cu/Zn-SOD activity compared to colitis group. AA administration
significantly increased the levels of plasma MDA in comparison
with controls. However, NAC and LCAR administration to the
AA-treated rats significantly reduced the MDA levels compared to
colitis group. In conclusion NAC and LCAR could be beneficial
agents in restoring the circulating proinflammatory mediators. |
| format | Article |
| id | doaj-art-c36fd74b064e4ad9ad69206e8586ec41 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c36fd74b064e4ad9ad69206e8586ec412025-02-03T01:30:00ZengWileyMediators of Inflammation0962-93511466-18612005-01-012005639039410.1155/MI.2005.390Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental ColitisErgul Belge Kurutas0Ali Cetinkaya1Ertan Bulbuloglu2Bulent Kantarceken3Department of Biochemistry, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of General Surgery, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, TurkeyDepartment of Gastroenterology, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, TurkeyThe aim of the present study was to evaluate the effects of N-acetylcysteine (NAC) and L-carnitine (LCAR) supplementations on polymorphonuclear leukocytes myeloperoxidase (MPO) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde (MDA) in acetic acid (AA)-induced ulcerative colitis model. The mean polymorphonuclear leukocyte MPO and Cu/Zn-SOD activity was significantly higher in the colitis group than in the control group. Both NAC and LCAR pretreatment markedly decreased MPO and Cu/Zn-SOD activity compared to colitis group. AA administration significantly increased the levels of plasma MDA in comparison with controls. However, NAC and LCAR administration to the AA-treated rats significantly reduced the MDA levels compared to colitis group. In conclusion NAC and LCAR could be beneficial agents in restoring the circulating proinflammatory mediators.http://dx.doi.org/10.1155/MI.2005.390 |
| spellingShingle | Ergul Belge Kurutas Ali Cetinkaya Ertan Bulbuloglu Bulent Kantarceken Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental Colitis Mediators of Inflammation |
| title | Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and
Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental
Colitis |
| title_full | Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and
Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental
Colitis |
| title_fullStr | Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and
Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental
Colitis |
| title_full_unstemmed | Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and
Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental
Colitis |
| title_short | Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and
Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental
Colitis |
| title_sort | effects of antioxidant therapy on leukocyte myeloperoxidase and cu zn superoxide dismutase and plasma malondialdehyde levels in experimental colitis |
| url | http://dx.doi.org/10.1155/MI.2005.390 |
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