Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental Colitis
The aim of the present study was to evaluate the effects of N-acetylcysteine (NAC) and L-carnitine (LCAR) supplementations on polymorphonuclear leukocytes myeloperoxidase (MPO) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde (MDA) in acetic acid (AA)-induced ulcerative colitis...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.390 |
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| Summary: | The aim of the present study was to evaluate the effects of
N-acetylcysteine (NAC) and L-carnitine (LCAR) supplementations on
polymorphonuclear leukocytes myeloperoxidase (MPO) and
Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde
(MDA) in acetic acid (AA)-induced ulcerative colitis model. The
mean polymorphonuclear leukocyte MPO and Cu/Zn-SOD activity was
significantly higher in the colitis group than in the control
group. Both NAC and LCAR pretreatment markedly decreased MPO and
Cu/Zn-SOD activity compared to colitis group. AA administration
significantly increased the levels of plasma MDA in comparison
with controls. However, NAC and LCAR administration to the
AA-treated rats significantly reduced the MDA levels compared to
colitis group. In conclusion NAC and LCAR could be beneficial
agents in restoring the circulating proinflammatory mediators. |
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| ISSN: | 0962-9351 1466-1861 |