Hypopigmented Mycosis Fungoides: A Retrospective Study
Background: Hypopigmented mycosis fungoides (HMF) is a rare cutaneous T-cell lymphoma seen in children with persistent hypopigmented patches, histopathology showing epidermotropism of atypical lymphocytes, and immunohistochemistry being predominantly CD8+. Methodology: A cross-sectional retrospectiv...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Current Medical Issues |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/cmi.cmi_146_24 |
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| Summary: | Background:
Hypopigmented mycosis fungoides (HMF) is a rare cutaneous T-cell lymphoma seen in children with persistent hypopigmented patches, histopathology showing epidermotropism of atypical lymphocytes, and immunohistochemistry being predominantly CD8+.
Methodology:
A cross-sectional retrospective study on patients with HMF between June 2009 and January 2024 at a tertiary care center in South India was done. The clinical profile of the patients, serology, and histopathology with immunohistochemistry were reviewed.
Results:
Of 34 patients included in the study, the mean age at presentation was 32.65 ± 13.25 years, duration of symptoms was 5.33 ± 0.83 years, and the mean age at onset was 27.29 ± 2.73 years. All but one patient had multiple patches, 18(53%) with both covered and photo-exposed sites and 14(41%) having only over covered sites. Nine patients presented with mixed morphology of lesions along with hypopigmented patches. Seventeen (50%) patients had more than 10% body surface area involved, none had systemic disease. Histopathology revealed epidermotropism (100%) and lymphocyte tagging (82%). Immunohistochemistry showed CD8 predominance in 56%. Of the patients with only hypopigmented lesions, 64% showed CD8+ predominance, and 67% of patients with mixed morphology had CD4+ predominance.
Conclusions:
HMF should be considered in patients with persistent hypopigmented patches predominantly over covered areas. Usually, HMF has an earlier age of onset, but our study had a mean age at onset of 27 years. Hypopigmented lesions were mostly CD8+ and mixed morphology of lesions were mostly CD4+ on immunohistochemistry. |
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| ISSN: | 0973-4651 2666-4054 |