Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity
Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Long-term exposure to acrylamide (AA) can cause liver injury and endanger human health. However, whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clea...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001131 |
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| author | Linzi Li Xueying Lei Lin Chen Ya Ma Jun Luo Xuebo Liu Xinglian Xu Guanghong Zhou Xianchao Feng |
| author_facet | Linzi Li Xueying Lei Lin Chen Ya Ma Jun Luo Xuebo Liu Xinglian Xu Guanghong Zhou Xianchao Feng |
| author_sort | Linzi Li |
| collection | DOAJ |
| description | Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Long-term exposure to acrylamide (AA) can cause liver injury and endanger human health. However, whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear. Here, we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro. In vivo studies found that quercetin-like compounds protect against AA-induced liver injury by reducing oxidative stress levels, activating the Akt/mTOR signaling pathway to attenuate autophagy, and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis. In vitro studies found that quercetin compounds protected HepG2 cells from AA by attenuating the activation of AA-induced autophagy, lowering reactive oxygen species (ROS) levels by exerting antioxidant effects and thus attenuating oxidative stress, increasing mitochondrial membrane potential (MMP), and improving apoptosis-related proteins, thus attenuating AA-induced apoptosis. Furthermore, the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity, with quercetin showing the best protective capacity due to its strongest antioxidant activity. In conclusion, quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress, autophagy and apoptosis, and their protective capacity correlates with antioxidant activity. |
| format | Article |
| id | doaj-art-c347e24876de4fa0bd27d82f5ff48aaa |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-c347e24876de4fa0bd27d82f5ff48aaa2025-02-03T06:57:18ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131225240Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicityLinzi Li0Xueying Lei1Lin Chen2Ya Ma3Jun Luo4Xuebo Liu5Xinglian Xu6Guanghong Zhou7Xianchao Feng8College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China; Corresponding author at: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaSynergetic Innovation Center of Food Safety and Nutrition, Key Laboratory of Meat Processing and Quality Control, Ministry of Education, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaSynergetic Innovation Center of Food Safety and Nutrition, Key Laboratory of Meat Processing and Quality Control, Ministry of Education, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, China; Corresponding author at: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Long-term exposure to acrylamide (AA) can cause liver injury and endanger human health. However, whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear. Here, we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro. In vivo studies found that quercetin-like compounds protect against AA-induced liver injury by reducing oxidative stress levels, activating the Akt/mTOR signaling pathway to attenuate autophagy, and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis. In vitro studies found that quercetin compounds protected HepG2 cells from AA by attenuating the activation of AA-induced autophagy, lowering reactive oxygen species (ROS) levels by exerting antioxidant effects and thus attenuating oxidative stress, increasing mitochondrial membrane potential (MMP), and improving apoptosis-related proteins, thus attenuating AA-induced apoptosis. Furthermore, the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity, with quercetin showing the best protective capacity due to its strongest antioxidant activity. In conclusion, quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress, autophagy and apoptosis, and their protective capacity correlates with antioxidant activity.http://www.sciencedirect.com/science/article/pii/S2213453023001131Quercetin compoundsAcrylamideProtection mechanismOxidative stressAntioxidant activity |
| spellingShingle | Linzi Li Xueying Lei Lin Chen Ya Ma Jun Luo Xuebo Liu Xinglian Xu Guanghong Zhou Xianchao Feng Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity Food Science and Human Wellness Quercetin compounds Acrylamide Protection mechanism Oxidative stress Antioxidant activity |
| title | Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity |
| title_full | Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity |
| title_fullStr | Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity |
| title_full_unstemmed | Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity |
| title_short | Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity |
| title_sort | protective mechanism of quercetin compounds against acrylamide induced hepatotoxicity |
| topic | Quercetin compounds Acrylamide Protection mechanism Oxidative stress Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001131 |
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