Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia
ObjectiveLong non-coding RNA (lncRNA) is aberrantly expressed in a variety of tumor diseases. To date, its specific role in acute myeloid leukemia (AML) has not been fully elucidated. This study aims to evaluate the association between aberrant lncRNA expression and poor prognosis in AML patients, a...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1524449/full |
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| author | Guihong Liu Liangliang Sun Peng Lv Rong Qiao Lihang Wang Arong Jin |
| author_facet | Guihong Liu Liangliang Sun Peng Lv Rong Qiao Lihang Wang Arong Jin |
| author_sort | Guihong Liu |
| collection | DOAJ |
| description | ObjectiveLong non-coding RNA (lncRNA) is aberrantly expressed in a variety of tumor diseases. To date, its specific role in acute myeloid leukemia (AML) has not been fully elucidated. This study aims to evaluate the association between aberrant lncRNA expression and poor prognosis in AML patients, and to systematically assess the relationship between aberrant lncRNA expression and AML prognosis.MethodsWe conducted a comprehensive literature search in PubMed, Embase, Cochrane Library, CNKI (China National Knowledge Infrastructure), WanFang (China Wanfang Database), VIP (China VIP Database), and Sinomed (China Biomedical Literature Database) to identify relevant Chinese and English articles. The search period covered from the inception of these databases to 4 August 2024. Articles were screened according to predefined inclusion and exclusion criteria, and meta-analysis was performed using Stata.ResultsA total of 25 articles were included in the analysis. Aberrant lncRNA expression was significantly associated with reduced overall survival (univariate HR = 2.46, 95%CI 2.11–2.88, P < 0.001; multivariate HR = 2.46, 95%CI 2.11–2.88, P < 0.001), event-free survival (HR = 1.51, 95%CI 1.19–1.90, P = 0.001), recurrence-free survival (HR = 2.82, 95%CI 2.03–3.91, P < 0.001), and disease-free survival (HR = 2.390, 95%CI 1.037–5.507, P = 0.041). These findings were statistically significant. The 25 articles collectively identified 22 lncRNAs whose aberrant expression was associated with AML prognosis. Notably, multiple studies highlighted the aberrant expression of lncRNA CRNDE, ZEB2-AS1, and TUG1 as being particularly relevant to AML prognosis. Our meta-analysis revealed that high expression of lncRNA CRNDE and TUG1 was associated with reduced overall survival, while high expression of lncRNA ZEB2-AS1 was linked to decreased disease-free survival, both with statistically significant differences.ConclusionThe expression levels of lncRNAs are closely associated with the prognosis of AML patients and may serve as important indicators for monitoring prognosis in the future. However, further high-quality studies are needed to validate these findings. |
| format | Article |
| id | doaj-art-c33ff6afcf7c44f2aeffc3833f8f2128 |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-c33ff6afcf7c44f2aeffc3833f8f21282025-02-04T06:31:54ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-02-011610.3389/fgene.2025.15244491524449Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemiaGuihong Liu0Liangliang Sun1Peng Lv2Rong Qiao3Lihang Wang4Arong Jin5Graduate School, Inner Mongolia Medical University, Hohhot, ChinaInner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaInner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaInner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaGraduate School, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, ChinaInner Mongolia Autonomous Region People’s Hospital, Hohhot, ChinaObjectiveLong non-coding RNA (lncRNA) is aberrantly expressed in a variety of tumor diseases. To date, its specific role in acute myeloid leukemia (AML) has not been fully elucidated. This study aims to evaluate the association between aberrant lncRNA expression and poor prognosis in AML patients, and to systematically assess the relationship between aberrant lncRNA expression and AML prognosis.MethodsWe conducted a comprehensive literature search in PubMed, Embase, Cochrane Library, CNKI (China National Knowledge Infrastructure), WanFang (China Wanfang Database), VIP (China VIP Database), and Sinomed (China Biomedical Literature Database) to identify relevant Chinese and English articles. The search period covered from the inception of these databases to 4 August 2024. Articles were screened according to predefined inclusion and exclusion criteria, and meta-analysis was performed using Stata.ResultsA total of 25 articles were included in the analysis. Aberrant lncRNA expression was significantly associated with reduced overall survival (univariate HR = 2.46, 95%CI 2.11–2.88, P < 0.001; multivariate HR = 2.46, 95%CI 2.11–2.88, P < 0.001), event-free survival (HR = 1.51, 95%CI 1.19–1.90, P = 0.001), recurrence-free survival (HR = 2.82, 95%CI 2.03–3.91, P < 0.001), and disease-free survival (HR = 2.390, 95%CI 1.037–5.507, P = 0.041). These findings were statistically significant. The 25 articles collectively identified 22 lncRNAs whose aberrant expression was associated with AML prognosis. Notably, multiple studies highlighted the aberrant expression of lncRNA CRNDE, ZEB2-AS1, and TUG1 as being particularly relevant to AML prognosis. Our meta-analysis revealed that high expression of lncRNA CRNDE and TUG1 was associated with reduced overall survival, while high expression of lncRNA ZEB2-AS1 was linked to decreased disease-free survival, both with statistically significant differences.ConclusionThe expression levels of lncRNAs are closely associated with the prognosis of AML patients and may serve as important indicators for monitoring prognosis in the future. However, further high-quality studies are needed to validate these findings.https://www.frontiersin.org/articles/10.3389/fgene.2025.1524449/fulllong noncoding RNA (LncRNA)acute myeloid leukemia (AML)prognosismeta-analysisreview-systematic |
| spellingShingle | Guihong Liu Liangliang Sun Peng Lv Rong Qiao Lihang Wang Arong Jin Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia Frontiers in Genetics long noncoding RNA (LncRNA) acute myeloid leukemia (AML) prognosis meta-analysis review-systematic |
| title | Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia |
| title_full | Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia |
| title_fullStr | Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia |
| title_full_unstemmed | Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia |
| title_short | Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia |
| title_sort | systematic review and meta analysis of the impact of abnormal expression of long non coding rna on the prognosis of acute myeloid leukemia |
| topic | long noncoding RNA (LncRNA) acute myeloid leukemia (AML) prognosis meta-analysis review-systematic |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1524449/full |
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