Loeffler’s Endocarditis – Unforgiving Eosinophilic Damage to the Endocardium
Hypereosinophilic syndrome (HES) is defined as hypereosinophilia due to any cause (absolute eosinophil count > 1500 cells/μL) in the peripheral blood, which leads to eosinophil-mediated multiorgan damage. Cardiac involvement is a significant cause of morbidity and mortality among patients with HE...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jiae.jiae_43_24 |
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| Summary: | Hypereosinophilic syndrome (HES) is defined as hypereosinophilia due to any cause (absolute eosinophil count > 1500 cells/μL) in the peripheral blood, which leads to eosinophil-mediated multiorgan damage. Cardiac involvement is a significant cause of morbidity and mortality among patients with HES. Here, we discuss a case of eosinophilia-related endomyocardial involvement, also known as Loeffler’s endocarditis, a rare form of restrictive cardiomyopathy. Notably, on genetic analysis, he was found to have a rare FIP1-like-1-platelet-derived growth factor receptor alpha-associated myeloproliferative variant of HES, which responded to imatinib, making it one of the very few reported cases of such kind. |
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| ISSN: | 2543-1463 2543-1471 |