An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

<h4>Background</h4>Repeated use, coitus-independent microbicide gels that do not contain antiretroviral agents also used as first line HIV therapy are urgently needed to curb HIV spread. Current formulations require high doses (millimolar range) of antiretroviral drugs and typically only...

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Main Authors: Jessica Kenney, Meropi Aravantinou, Rachel Singer, Mayla Hsu, Aixa Rodriguez, Larisa Kizima, Ciby J Abraham, Radhika Menon, Samantha Seidor, Anne Chudolij, Agegnehu Gettie, James Blanchard, Jeffrey D Lifson, Michael Piatak, Jose A Fernández-Romero, Thomas M Zydowsky, Melissa Robbiani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015835&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015835&type=printable

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