Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept

Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept

ABSTRACT Podophyllotoxin (PPT), an extract from the traditional medicinal plant Dysosma, offers anti-viral and anti-cancer benefits, though its use is limited by toxicity. The mechanisms of PPT’s inherent pulmonary toxicity remain elusive. This study leverages the novel “Toxicological Evidence Chain...

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Bibliographic Details
Main Authors: Min Wang, Xiao Ma, Junjie He, Jiaxing Sun, Feng Cai, Chuanxin Liu, Jiajia Duan
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:Microbiology Spectrum
Subjects:
podophyllotoxin
pulmonary toxicity
gut microbiota
metabolome
microbiota-gut-lung axis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01653-24
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