A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test

Obstructive sleep apnea syndrome (OSAS) is a life-threatening disease characterized by upper airway narrowing or obstruction. The diagnostic process is difficult, costly, and time-consuming. Many individuals with OSAS do not apply for a diagnosis or are unaware of their disease. This study aimed to...

Full description

Saved in:
Bibliographic Details
Main Authors: Seval Bulut Eris, Mehmet Recep Bozkurt, Omer Eris, Cahit Bilgin
Format: Article
Language:English
Published: IEEE 2025-01-01
Series:IEEE Access
Subjects:
Online Access:https://ieeexplore.ieee.org/document/10845768/
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832583999949635584
author Seval Bulut Eris
Mehmet Recep Bozkurt
Omer Eris
Cahit Bilgin
author_facet Seval Bulut Eris
Mehmet Recep Bozkurt
Omer Eris
Cahit Bilgin
author_sort Seval Bulut Eris
collection DOAJ
description Obstructive sleep apnea syndrome (OSAS) is a life-threatening disease characterized by upper airway narrowing or obstruction. The diagnostic process is difficult, costly, and time-consuming. Many individuals with OSAS do not apply for a diagnosis or are unaware of their disease. This study aimed to develop a practical, fast, and reliable diagnostic system for early diagnosis and treatment of OSAS. For the first time, features were extracted from flow-volume curves obtained using a Pulmonary Function Test (PFT), and an Artificial Intelligence (AI)-based algorithm was developed to diagnose OSAS. Spearman correlation coefficients determined the degree of influence of the features in determining OSAS. Several models were created using different features and AI methods according to their effect levels. The models obtained by hyperparameter optimization and cross-validation were tested with unseen data, and their performance was evaluated using seven different criteria. Using only five features extracted from the flow-volume curve (TLC/PIF, PIF/PEF, TLC/FIF50, TLC/FIF25, and FIF25/FEF25), OSAS was diagnosed with 97.1% accuracy using the Neural Network (NN) algorithm. The results showed that OSAS can be diagnosed quickly and reliably using PFT available at every hospital. The features extracted from the flow-volume curve could be used as biomarkers for diagnosing OSAS. The proposed method can be adapted to PC-based spirometry devices without additional hardware developments. This is a significant innovation in both literature and practice. This method will enable early diagnosis for patients and many people unaware of their disease. This will shed light on several future studies.
format Article
id doaj-art-c30c085af3f24e9c8f60e0b395ff308e
institution Kabale University
issn 2169-3536
language English
publishDate 2025-01-01
publisher IEEE
record_format Article
series IEEE Access
spelling doaj-art-c30c085af3f24e9c8f60e0b395ff308e2025-01-28T00:01:17ZengIEEEIEEE Access2169-35362025-01-0113153761538910.1109/ACCESS.2025.353150110845768A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function TestSeval Bulut Eris0https://orcid.org/0000-0001-8681-1848Mehmet Recep Bozkurt1https://orcid.org/0000-0003-0673-4454Omer Eris2https://orcid.org/0000-0003-1687-5912Cahit Bilgin3Electrical and Electronics Engineering Department, Sakarya University, Sakarya, TürkiyeElectrical and Electronics Engineering Department, Sakarya University, Sakarya, TürkiyeElectrical and Electronics Engineering Department, Sakarya University, Sakarya, TürkiyeFaculty of Medicine, Sakarya University, Sakarya, TürkiyeObstructive sleep apnea syndrome (OSAS) is a life-threatening disease characterized by upper airway narrowing or obstruction. The diagnostic process is difficult, costly, and time-consuming. Many individuals with OSAS do not apply for a diagnosis or are unaware of their disease. This study aimed to develop a practical, fast, and reliable diagnostic system for early diagnosis and treatment of OSAS. For the first time, features were extracted from flow-volume curves obtained using a Pulmonary Function Test (PFT), and an Artificial Intelligence (AI)-based algorithm was developed to diagnose OSAS. Spearman correlation coefficients determined the degree of influence of the features in determining OSAS. Several models were created using different features and AI methods according to their effect levels. The models obtained by hyperparameter optimization and cross-validation were tested with unseen data, and their performance was evaluated using seven different criteria. Using only five features extracted from the flow-volume curve (TLC/PIF, PIF/PEF, TLC/FIF50, TLC/FIF25, and FIF25/FEF25), OSAS was diagnosed with 97.1% accuracy using the Neural Network (NN) algorithm. The results showed that OSAS can be diagnosed quickly and reliably using PFT available at every hospital. The features extracted from the flow-volume curve could be used as biomarkers for diagnosing OSAS. The proposed method can be adapted to PC-based spirometry devices without additional hardware developments. This is a significant innovation in both literature and practice. This method will enable early diagnosis for patients and many people unaware of their disease. This will shed light on several future studies.https://ieeexplore.ieee.org/document/10845768/Artificial intelligencebiomarkersfeature extractionflow-volume curveobstructive sleep apneapulmonary function test
spellingShingle Seval Bulut Eris
Mehmet Recep Bozkurt
Omer Eris
Cahit Bilgin
A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test
IEEE Access
Artificial intelligence
biomarkers
feature extraction
flow-volume curve
obstructive sleep apnea
pulmonary function test
title A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test
title_full A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test
title_fullStr A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test
title_full_unstemmed A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test
title_short A Huge Innovation in Diagnosis of Obstructive Sleep Apnea Syndrome: With an Artificial Intelligence-Based Algorithm, Obstructive Sleep Apnea Syndrome Can Now Be Diagnosed With Pulmonary Function Test
title_sort huge innovation in diagnosis of obstructive sleep apnea syndrome with an artificial intelligence based algorithm obstructive sleep apnea syndrome can now be diagnosed with pulmonary function test
topic Artificial intelligence
biomarkers
feature extraction
flow-volume curve
obstructive sleep apnea
pulmonary function test
url https://ieeexplore.ieee.org/document/10845768/
work_keys_str_mv AT sevalbuluteris ahugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT mehmetrecepbozkurt ahugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT omereris ahugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT cahitbilgin ahugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT sevalbuluteris hugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT mehmetrecepbozkurt hugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT omereris hugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest
AT cahitbilgin hugeinnovationindiagnosisofobstructivesleepapneasyndromewithanartificialintelligencebasedalgorithmobstructivesleepapneasyndromecannowbediagnosedwithpulmonaryfunctiontest