Syphacia obvelata antigens alter the FOXP3/RORɣt expression balance in isolated peripheral blood mononuclear cells of IBD patients

Syphacia obvelata antigens alter the FOXP3/RORɣt expression balance in isolated peripheral blood mononuclear cells of IBD patients

Abstract Inflammatory Bowel Disease (IBD) arises from disrupted interactions among intestinal microbiota, epithelial cells, and the immune system, which are influenced by genetic and environmental factors. A critical factor in IBD pathogenesis is the balance between FOXP3+ regulatory T cells (Tregs)...

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Bibliographic Details
Main Authors: Abbas Amin, Niloofar Taghipour, Mohammad Rostami-Nejad, Foroogh Alborzi Avanaki, Reyhaneh Jafarshad, Seyyed Javad Seyyed Tabaei, Nariman Mosaffa
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Syphacia obvelata
IBD
FOXP3
RORɣt
Online Access:https://doi.org/10.1038/s41598-025-06619-0
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