Senataxin prevents replicative stress induced by the Myc oncogene

Senataxin prevents replicative stress induced by the Myc oncogene

Abstract Replicative stress (RS) is emerging as a promising therapeutic target in oncology, yet full exploitation of its potential requires a detailed understanding of the mechanisms and genes involved. Here, we investigated the RNA helicase Senataxin (SETX), an enzyme that resolves RNA-DNA hybrids...

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Main Authors: Silvia Sberna, Marco Filipuzzi, Nicola Bianchi, Ottavio Croci, Federica Fardella, Chiara Soriani, Sara Rohban, Sara Carnevali, Alessandra Alberta Albertini, Nicola Crosetto, Simona Rodighiero, Arianna Chiesa, Laura Curti, Stefano Campaner
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07485-4
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https://doi.org/10.1038/s41419-025-07485-4

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