Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series
We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [18F]-2'-fluoro-2'-deoxy-D-glucose ([18F]-FDG) and [18F]-fluorocholine ([18F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_91_18 |
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| author | Tanyaluck Thientunyakit Thonnapong Thongpraparn Tossaporn Siriprapa Juri G. Gelovani |
| author_facet | Tanyaluck Thientunyakit Thonnapong Thongpraparn Tossaporn Siriprapa Juri G. Gelovani |
| author_sort | Tanyaluck Thientunyakit |
| collection | DOAJ |
| description | We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [18F]-2'-fluoro-2'-deoxy-D-glucose ([18F]-FDG) and [18F]-fluorocholine ([18F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [18F]-FDG and [18F]-FCH was performed in three patients with GTN in 2 consecutive days. Each detectable lesion was characterized by visual and quantitative analyses. As compared to CT alone, PET/CT with [18F]-FDG and [18F]-FCH PET/CT revealed more hypermetabolic metastatic lesions in the body, but not in the brain. The standard uptake value of [18F]-FDG was generally higher than [18F]-FCH in all detectable tumor lesions. In conclusion, both [18F]-FDG and [18F]-FCH PET/CT can be used for diagnosis and staging for GTN, based on their sensitivity for small extracerebral metastatic lesions. Additional studies are warranted to determine whether the PET/CT imaging with [18F]-FDG and [18F]-FCH can serve as a biomarker of GTN aggressiveness, for prediction of treatment response. |
| format | Article |
| id | doaj-art-c2fef4caa0ca4e8aaa0ff2511ffc8fcf |
| institution | DOAJ |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
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| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-c2fef4caa0ca4e8aaa0ff2511ffc8fcf2025-08-20T02:54:42ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122020-01-011901727710.4103/wjnm.WJNM_91_18Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case seriesTanyaluck Thientunyakit0Thonnapong Thongpraparn1Tossaporn Siriprapa2Juri G. Gelovani3Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Neurosurgery, Oncology, OBGYN, Biomedical Engineering, School of Medicine, College of Engineering, and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USAWe report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [18F]-2'-fluoro-2'-deoxy-D-glucose ([18F]-FDG) and [18F]-fluorocholine ([18F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [18F]-FDG and [18F]-FCH was performed in three patients with GTN in 2 consecutive days. Each detectable lesion was characterized by visual and quantitative analyses. As compared to CT alone, PET/CT with [18F]-FDG and [18F]-FCH PET/CT revealed more hypermetabolic metastatic lesions in the body, but not in the brain. The standard uptake value of [18F]-FDG was generally higher than [18F]-FCH in all detectable tumor lesions. In conclusion, both [18F]-FDG and [18F]-FCH PET/CT can be used for diagnosis and staging for GTN, based on their sensitivity for small extracerebral metastatic lesions. Additional studies are warranted to determine whether the PET/CT imaging with [18F]-FDG and [18F]-FCH can serve as a biomarker of GTN aggressiveness, for prediction of treatment response.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_91_18[18f]-2'-fluoro-2'-deoxy-d-glucose[18f]-fluorocholinechoriocarcinomagestational trophoblastic neoplasiapositron emission tomography/computed tomography |
| spellingShingle | Tanyaluck Thientunyakit Thonnapong Thongpraparn Tossaporn Siriprapa Juri G. Gelovani Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series World Journal of Nuclear Medicine [18f]-2'-fluoro-2'-deoxy-d-glucose [18f]-fluorocholine choriocarcinoma gestational trophoblastic neoplasia positron emission tomography/computed tomography |
| title | Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series |
| title_full | Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series |
| title_fullStr | Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series |
| title_full_unstemmed | Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series |
| title_short | Head-to-head comparison of [18F]-fluorodeoxyglucose and [18F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series |
| title_sort | head to head comparison of 18f fluorodeoxyglucose and 18f fluorocholine positron emission tomography computed tomography in three patients with rare gestational trophoblastic neoplasms a case series |
| topic | [18f]-2'-fluoro-2'-deoxy-d-glucose [18f]-fluorocholine choriocarcinoma gestational trophoblastic neoplasia positron emission tomography/computed tomography |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_91_18 |
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