MicroRNAs in Cerebral Ischemia
The risk of ischemic stroke increases substantially with age, making it the third leading cause of death and the leading cause of long-term disability in the world. Numerous studies demonstrated that genes, RNAs, and proteins are involved in the occurrence and development of stroke. Current studies...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/276540 |
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| _version_ | 1832553969437638656 |
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| author | Yang Wang Yongting Wang Guo-Yuan Yang |
| author_facet | Yang Wang Yongting Wang Guo-Yuan Yang |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | The risk of ischemic stroke increases substantially with age, making it the third leading cause of death and the leading cause of long-term disability in the world. Numerous studies demonstrated that genes, RNAs, and proteins are involved in the occurrence and development of stroke. Current studies found that microRNAs (miRNAs or miRs) are also closely related to the pathological process of stroke. miRNAs are a group of short, noncoding RNA molecules playing important role in posttranscriptional regulation of gene expression and they have emerged as regulators of ischemic preconditioning and ischemic postconditioning. Here we give an overview of the expression and function of miRNAs in the brain, miRNAs as biomarkers during cerebral ischemia, and clinical applications and limitations of miRNAs. Future prospects of miRNAs are also discussed. |
| format | Article |
| id | doaj-art-c2f22ff40a4343b2a54cd0ebc6a539e8 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-c2f22ff40a4343b2a54cd0ebc6a539e82025-02-03T05:52:50ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/276540276540MicroRNAs in Cerebral IschemiaYang Wang0Yongting Wang1Guo-Yuan Yang2Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaNeuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaThe risk of ischemic stroke increases substantially with age, making it the third leading cause of death and the leading cause of long-term disability in the world. Numerous studies demonstrated that genes, RNAs, and proteins are involved in the occurrence and development of stroke. Current studies found that microRNAs (miRNAs or miRs) are also closely related to the pathological process of stroke. miRNAs are a group of short, noncoding RNA molecules playing important role in posttranscriptional regulation of gene expression and they have emerged as regulators of ischemic preconditioning and ischemic postconditioning. Here we give an overview of the expression and function of miRNAs in the brain, miRNAs as biomarkers during cerebral ischemia, and clinical applications and limitations of miRNAs. Future prospects of miRNAs are also discussed.http://dx.doi.org/10.1155/2013/276540 |
| spellingShingle | Yang Wang Yongting Wang Guo-Yuan Yang MicroRNAs in Cerebral Ischemia Stroke Research and Treatment |
| title | MicroRNAs in Cerebral Ischemia |
| title_full | MicroRNAs in Cerebral Ischemia |
| title_fullStr | MicroRNAs in Cerebral Ischemia |
| title_full_unstemmed | MicroRNAs in Cerebral Ischemia |
| title_short | MicroRNAs in Cerebral Ischemia |
| title_sort | micrornas in cerebral ischemia |
| url | http://dx.doi.org/10.1155/2013/276540 |
| work_keys_str_mv | AT yangwang micrornasincerebralischemia AT yongtingwang micrornasincerebralischemia AT guoyuanyang micrornasincerebralischemia |