Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome
Importance. Rituximab was not effective in ameliorating the hearing loss in a patient with atypical Cogan’s syndrome. Observations. We report the case of a patient who developed acute bilateral uveitis and sensorineural hearing loss. A diagnosis of atypical Cogan’s syndrome was made. The patient’s h...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2016/8352893 |
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| author | Daniel R. Bunker Leslie Dubin Kerr |
| author_facet | Daniel R. Bunker Leslie Dubin Kerr |
| author_sort | Daniel R. Bunker |
| collection | DOAJ |
| description | Importance. Rituximab was not effective in ameliorating the hearing loss in a patient with atypical Cogan’s syndrome. Observations. We report the case of a patient who developed acute bilateral uveitis and sensorineural hearing loss. A diagnosis of atypical Cogan’s syndrome was made. The patient’s hearing loss did not improve despite high dose steroids and azathioprine. Rituximab was administered given a recent report of its efficacy in a patient with refractory disease; however, our patient’s hearing loss did not improve. Conclusion. Hearing loss in Cogan’s syndrome is difficult to treat. Though rituximab was ineffective in our case, earlier administration in the disease course could be effective for future patients. |
| format | Article |
| id | doaj-art-c2ec41baac5042089d3adc992704ac4e |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-c2ec41baac5042089d3adc992704ac4e2025-02-03T01:20:26ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/83528938352893Rituximab Not Effective for Hearing Loss in Cogan’s SyndromeDaniel R. Bunker0Leslie Dubin Kerr1Department of Medicine, Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Medicine, Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAImportance. Rituximab was not effective in ameliorating the hearing loss in a patient with atypical Cogan’s syndrome. Observations. We report the case of a patient who developed acute bilateral uveitis and sensorineural hearing loss. A diagnosis of atypical Cogan’s syndrome was made. The patient’s hearing loss did not improve despite high dose steroids and azathioprine. Rituximab was administered given a recent report of its efficacy in a patient with refractory disease; however, our patient’s hearing loss did not improve. Conclusion. Hearing loss in Cogan’s syndrome is difficult to treat. Though rituximab was ineffective in our case, earlier administration in the disease course could be effective for future patients.http://dx.doi.org/10.1155/2016/8352893 |
| spellingShingle | Daniel R. Bunker Leslie Dubin Kerr Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome Case Reports in Rheumatology |
| title | Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome |
| title_full | Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome |
| title_fullStr | Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome |
| title_full_unstemmed | Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome |
| title_short | Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome |
| title_sort | rituximab not effective for hearing loss in cogan s syndrome |
| url | http://dx.doi.org/10.1155/2016/8352893 |
| work_keys_str_mv | AT danielrbunker rituximabnoteffectiveforhearinglossincoganssyndrome AT lesliedubinkerr rituximabnoteffectiveforhearinglossincoganssyndrome |