The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients
Knowledge about the influence of inflammation on platelet function and relocation of hemostatic balance to hypercoagulable state is still unclear. We compared two groups of patients who suffer from acute vs. chronic inflammatory process and additionally present high on-treatment platelet reactivity-...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/3767128 |
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| author | Grzegorz Biolik Dariusz Gajniak Maciej Kubicz Damian Ziaja Krzysztof Ziaja Wacław Kuczmik |
| author_facet | Grzegorz Biolik Dariusz Gajniak Maciej Kubicz Damian Ziaja Krzysztof Ziaja Wacław Kuczmik |
| author_sort | Grzegorz Biolik |
| collection | DOAJ |
| description | Knowledge about the influence of inflammation on platelet function and relocation of hemostatic balance to hypercoagulable state is still unclear. We compared two groups of patients who suffer from acute vs. chronic inflammatory process and additionally present high on-treatment platelet reactivity-dual platelet resistance. We did not found any differences in platelet aggregation between both investigated groups, but patients who suffer from chronic inflammation presented stronger relocation of the hemostatic balance to the hypercoagulability. A high concentration of prothrombin fragment F1+2 together with higher activity of von Willebrand factor in critical limb ischemia shows more exaggerated fibrinogen turnover although the blood concentration of this factor was in normal range. We concluded that high on-treatment platelet reactivity-dual platelet resistance and intensified inflammation are linked with elevated platelet and fibrinogen turnover to counteract proper hemostatic balance in favor of a prothrombotic state. |
| format | Article |
| id | doaj-art-c2e015cc948e461b806d3ee4278c59c0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c2e015cc948e461b806d3ee4278c59c02025-02-03T01:00:01ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/37671283767128The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) PatientsGrzegorz Biolik0Dariusz Gajniak1Maciej Kubicz2Damian Ziaja3Krzysztof Ziaja4Wacław Kuczmik5Department of General, Vascular Surgery, Angiology and Phlebology Faculty of Katowice Medical University of Silesia, Faculty of Medicine in Katowice, Medical University of Silesia, Poniatowskiego Str 15, 40-055 Katowice, PolandDepartment of Anaesthesiology and Intensive Care, Upper-Silesian Medical Centre of the Silesian Medical University, Ziołowa 45, 40-635 Katowice, PolandDepartment of General, Vascular Surgery, Angiology and Phlebology Faculty of Katowice Medical University of Silesia, Faculty of Medicine in Katowice, Medical University of Silesia, Poniatowskiego Str 15, 40-055 Katowice, PolandPhysiotherapy Unit, Department of Physiotherapy, Faculty of Health Sciences, Medical University of Silesia, Poniatowskiego Str 15, 40-055 Katowice, PolandDepartment of General, Vascular Surgery, Angiology and Phlebology Faculty of Katowice Medical University of Silesia, Faculty of Medicine in Katowice, Medical University of Silesia, Poniatowskiego Str 15, 40-055 Katowice, PolandDepartment of General, Vascular Surgery, Angiology and Phlebology Faculty of Katowice Medical University of Silesia, Faculty of Medicine in Katowice, Medical University of Silesia, Poniatowskiego Str 15, 40-055 Katowice, PolandKnowledge about the influence of inflammation on platelet function and relocation of hemostatic balance to hypercoagulable state is still unclear. We compared two groups of patients who suffer from acute vs. chronic inflammatory process and additionally present high on-treatment platelet reactivity-dual platelet resistance. We did not found any differences in platelet aggregation between both investigated groups, but patients who suffer from chronic inflammation presented stronger relocation of the hemostatic balance to the hypercoagulability. A high concentration of prothrombin fragment F1+2 together with higher activity of von Willebrand factor in critical limb ischemia shows more exaggerated fibrinogen turnover although the blood concentration of this factor was in normal range. We concluded that high on-treatment platelet reactivity-dual platelet resistance and intensified inflammation are linked with elevated platelet and fibrinogen turnover to counteract proper hemostatic balance in favor of a prothrombotic state.http://dx.doi.org/10.1155/2019/3767128 |
| spellingShingle | Grzegorz Biolik Dariusz Gajniak Maciej Kubicz Damian Ziaja Krzysztof Ziaja Wacław Kuczmik The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients Mediators of Inflammation |
| title | The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients |
| title_full | The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients |
| title_fullStr | The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients |
| title_full_unstemmed | The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients |
| title_short | The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients |
| title_sort | influence of inflammation on fibrinogen turnover and redistribution of the hemostatic balance to a prothrombotic state in high on treatment platelet reactivity dual poor responder htpr dpr patients |
| url | http://dx.doi.org/10.1155/2019/3767128 |
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