Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction

Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have dem...

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Main Authors: Barbara Rinaldi, Francesca Guida, Anna Furiano, Maria Donniacuo, Livio Luongo, Giulia Gritti, Konrad Urbanek, Giovanni Messina, Sabatino Maione, Francesco Rossi, Vito de Novellis
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2015/265967
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author Barbara Rinaldi
Francesca Guida
Anna Furiano
Maria Donniacuo
Livio Luongo
Giulia Gritti
Konrad Urbanek
Giovanni Messina
Sabatino Maione
Francesco Rossi
Vito de Novellis
author_facet Barbara Rinaldi
Francesca Guida
Anna Furiano
Maria Donniacuo
Livio Luongo
Giulia Gritti
Konrad Urbanek
Giovanni Messina
Sabatino Maione
Francesco Rossi
Vito de Novellis
author_sort Barbara Rinaldi
collection DOAJ
description Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise.
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institution Kabale University
issn 2090-5904
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language English
publishDate 2015-01-01
publisher Wiley
record_format Article
series Neural Plasticity
spelling doaj-art-c2de7019f1de4a2390c63ed19b6df4202025-02-03T07:26:01ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/265967265967Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial InfarctionBarbara Rinaldi0Francesca Guida1Anna Furiano2Maria Donniacuo3Livio Luongo4Giulia Gritti5Konrad Urbanek6Giovanni Messina7Sabatino Maione8Francesco Rossi9Vito de Novellis10Department of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyMyocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise.http://dx.doi.org/10.1155/2015/265967
spellingShingle Barbara Rinaldi
Francesca Guida
Anna Furiano
Maria Donniacuo
Livio Luongo
Giulia Gritti
Konrad Urbanek
Giovanni Messina
Sabatino Maione
Francesco Rossi
Vito de Novellis
Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
Neural Plasticity
title Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
title_full Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
title_fullStr Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
title_full_unstemmed Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
title_short Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
title_sort effect of prolonged moderate exercise on the changes of nonneuronal cells in early myocardial infarction
url http://dx.doi.org/10.1155/2015/265967
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