Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have dem...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/265967 |
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| author | Barbara Rinaldi Francesca Guida Anna Furiano Maria Donniacuo Livio Luongo Giulia Gritti Konrad Urbanek Giovanni Messina Sabatino Maione Francesco Rossi Vito de Novellis |
| author_facet | Barbara Rinaldi Francesca Guida Anna Furiano Maria Donniacuo Livio Luongo Giulia Gritti Konrad Urbanek Giovanni Messina Sabatino Maione Francesco Rossi Vito de Novellis |
| author_sort | Barbara Rinaldi |
| collection | DOAJ |
| description | Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise. |
| format | Article |
| id | doaj-art-c2de7019f1de4a2390c63ed19b6df420 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c2de7019f1de4a2390c63ed19b6df4202025-02-03T07:26:01ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/265967265967Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial InfarctionBarbara Rinaldi0Francesca Guida1Anna Furiano2Maria Donniacuo3Livio Luongo4Giulia Gritti5Konrad Urbanek6Giovanni Messina7Sabatino Maione8Francesco Rossi9Vito de Novellis10Department of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, ItalyMyocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise.http://dx.doi.org/10.1155/2015/265967 |
| spellingShingle | Barbara Rinaldi Francesca Guida Anna Furiano Maria Donniacuo Livio Luongo Giulia Gritti Konrad Urbanek Giovanni Messina Sabatino Maione Francesco Rossi Vito de Novellis Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction Neural Plasticity |
| title | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
| title_full | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
| title_fullStr | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
| title_full_unstemmed | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
| title_short | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
| title_sort | effect of prolonged moderate exercise on the changes of nonneuronal cells in early myocardial infarction |
| url | http://dx.doi.org/10.1155/2015/265967 |
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