Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells
Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetal β-cell is unknown. We measured the impact of one wee...
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Main Authors: | Mackenzie S. Frost, Aqib H. Zehri, Sean W. Limesand, William W. Hay, Paul J. Rozance |
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Format: | Article |
Language: | English |
Published: |
Wiley
2012-01-01
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Series: | Journal of Pregnancy |
Online Access: | http://dx.doi.org/10.1155/2012/812094 |
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