Innate immune responses to bacterial ligands in the peripheral human lung--role of alveolar epithelial TLR expression and signalling.

Innate immune responses to bacterial ligands in the peripheral human lung--role of alveolar epithelial TLR expression and signalling.

It is widely believed that the alveolar epithelium is unresponsive to LPS, in the absence of serum, due to low expression of TLR4 and CD14. Furthermore, the responsiveness of the epithelium to TLR-2 ligands is also poorly understood. We hypothesised that human alveolar type I (ATI) and type II (ATII...

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Main Authors: Andrew J Thorley, Davide Grandolfo, Eric Lim, Peter Goldstraw, Alan Young, Teresa D Tetley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021827&type=printable
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