Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China
Rotavirus A (RVA) is the primary enteric pathogen of humans and many other species. However, RVA interspecies transmission remains poorly understood. In this study, we conducted a comprehensive screening and genotyping analysis of RVA in 1706 wild animal samples collected from various regions within...
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MDPI AG
2025-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/145 |
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| author | Xiang Le Yinzhu Tao Binghui Wang Yutong Hou Yuting Ning Junjie Hou Ruimei Wang Qian Li Xueshan Xia |
| author_facet | Xiang Le Yinzhu Tao Binghui Wang Yutong Hou Yuting Ning Junjie Hou Ruimei Wang Qian Li Xueshan Xia |
| author_sort | Xiang Le |
| collection | DOAJ |
| description | Rotavirus A (RVA) is the primary enteric pathogen of humans and many other species. However, RVA interspecies transmission remains poorly understood. In this study, we conducted a comprehensive screening and genotyping analysis of RVA in 1706 wild animal samples collected from various regions within Yunnan Province, China. A total of 24 samples, originating from wild boars, rodents, bats, and birds tested positive for RVA. Next generation sequencing and phylogenetic analyses revealed a high degree of genetic diversity and reassortment, particularly for VP4 and VP7. Strains isolated from wild boars and rodents exhibited gene segments with high similarity to those found in humans and other mammalian RVA strains, indicating that RVA may undergo interspecies transmission and reassortment, resulting in novel strains with potential risks for human infection. This study provides critical data for understanding the transmission mechanisms and the RVA host range, and highlights the pivotal role of wildlife in viral evolution and dissemination. These findings have significant implications for public health policies and emphasize the need for enhanced surveillance to prevent interspecies RVA transmission. |
| format | Article |
| id | doaj-art-c2bb7cf250fa47c38338eaf2a1c0ea5d |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-c2bb7cf250fa47c38338eaf2a1c0ea5d2025-01-24T13:42:49ZengMDPI AGMicroorganisms2076-26072025-01-0113114510.3390/microorganisms13010145Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, ChinaXiang Le0Yinzhu Tao1Binghui Wang2Yutong Hou3Yuting Ning4Junjie Hou5Ruimei Wang6Qian Li7Xueshan Xia8Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaYunnan Province Key Laboratory of Public Health and Biosafety, School of Public Health, Kunming Medical University, Kunming 650500, ChinaYunnan Province Key Laboratory of Public Health and Biosafety, School of Public Health, Kunming Medical University, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaClinical Medical College, Dali University, Dali 671000, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, ChinaRotavirus A (RVA) is the primary enteric pathogen of humans and many other species. However, RVA interspecies transmission remains poorly understood. In this study, we conducted a comprehensive screening and genotyping analysis of RVA in 1706 wild animal samples collected from various regions within Yunnan Province, China. A total of 24 samples, originating from wild boars, rodents, bats, and birds tested positive for RVA. Next generation sequencing and phylogenetic analyses revealed a high degree of genetic diversity and reassortment, particularly for VP4 and VP7. Strains isolated from wild boars and rodents exhibited gene segments with high similarity to those found in humans and other mammalian RVA strains, indicating that RVA may undergo interspecies transmission and reassortment, resulting in novel strains with potential risks for human infection. This study provides critical data for understanding the transmission mechanisms and the RVA host range, and highlights the pivotal role of wildlife in viral evolution and dissemination. These findings have significant implications for public health policies and emphasize the need for enhanced surveillance to prevent interspecies RVA transmission.https://www.mdpi.com/2076-2607/13/1/145Rotavirus Ainterspecies transmissionmammalian rotavirus A |
| spellingShingle | Xiang Le Yinzhu Tao Binghui Wang Yutong Hou Yuting Ning Junjie Hou Ruimei Wang Qian Li Xueshan Xia Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China Microorganisms Rotavirus A interspecies transmission mammalian rotavirus A |
| title | Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China |
| title_full | Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China |
| title_fullStr | Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China |
| title_full_unstemmed | Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China |
| title_short | Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China |
| title_sort | diversity and potential cross species transmission of rotavirus a in wild animals in yunnan china |
| topic | Rotavirus A interspecies transmission mammalian rotavirus A |
| url | https://www.mdpi.com/2076-2607/13/1/145 |
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