Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis
Abstract Background Surgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Theref...
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2025-01-01
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| author | Motoi Uchino Koji Tamura Shinsuke Nomura Seiichi Shinji Keita Kouzu Hiroji Shinkawa Tomohiro Ishinuki Toru Mizuguchi Hiroki Ohge Seiji Haji Junzo Shimizu Yasuhiko Mohri Chizuru Yamashita Yuichi Kitagawa Katsunori Suzuki Motomu Kobayash Masahiro Kobayashi Yuki Hanai Hiroshi Nobuhara Hiroki Imaoka Masahiro Yoshida Toshihiko Mayumi Hiroki Ikeuchi on behalf of SSI Prevention Guideline Committee in Japan Society for Surgical Infection |
| author_facet | Motoi Uchino Koji Tamura Shinsuke Nomura Seiichi Shinji Keita Kouzu Hiroji Shinkawa Tomohiro Ishinuki Toru Mizuguchi Hiroki Ohge Seiji Haji Junzo Shimizu Yasuhiko Mohri Chizuru Yamashita Yuichi Kitagawa Katsunori Suzuki Motomu Kobayash Masahiro Kobayashi Yuki Hanai Hiroshi Nobuhara Hiroki Imaoka Masahiro Yoshida Toshihiko Mayumi Hiroki Ikeuchi on behalf of SSI Prevention Guideline Committee in Japan Society for Surgical Infection |
| author_sort | Motoi Uchino |
| collection | DOAJ |
| description | Abstract Background Surgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy of antiseptic/antibiotic solution during wound irrigation or peritoneal lavage in gastroenterological surgery. Methods The database search used PubMed, MEDLINE, and Cochrane Library. The following inclusion criteria were set for the systematic review. 1) Studies comparing with or without antiseptic/antibiotic irrigation/lavage during gastrointestinal surgery. 2) Studies that described surgical site infections and adverse events. 3) Studies conducted after 2000. Results A total of 8 randomized controlled studies (RCTs) and 3 observational studies were included in this meta-analysis. Three RCTs of wound irrigation with povidone iodine (PVI) solution revealed no significant difference between the PVI and control groups [RR 1.41, 95% CI (0.92 to 2.17): p = 0.69]. Three RCTs of peritoneal lavage with antibiotic solution showed no significant difference between the interventional group and control groups [RR 0.39, 95% CI (0.10 to 1.55): p = 0.18]. Regarding other antiseptic or antibiotic solutions, the number of studies and participants were too small for evaluation. Conclusion Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution did not have enough efficacy for preventing SSI during gastroenterological surgery. |
| format | Article |
| id | doaj-art-c2b0e48f70c5411abccedf88b03e194e |
| institution | Kabale University |
| issn | 1471-2482 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Surgery |
| spelling | doaj-art-c2b0e48f70c5411abccedf88b03e194e2025-01-26T12:12:40ZengBMCBMC Surgery1471-24822025-01-012511910.1186/s12893-025-02774-3Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysisMotoi Uchino0Koji Tamura1Shinsuke Nomura2Seiichi Shinji3Keita Kouzu4Hiroji Shinkawa5Tomohiro Ishinuki6Toru Mizuguchi7Hiroki Ohge8Seiji Haji9Junzo Shimizu10Yasuhiko Mohri11Chizuru Yamashita12Yuichi Kitagawa13Katsunori Suzuki14Motomu Kobayash15Masahiro Kobayashi16Yuki Hanai17Hiroshi Nobuhara18Hiroki Imaoka19Masahiro Yoshida20Toshihiko Mayumi21Hiroki Ikeuchi22on behalf of SSI Prevention Guideline Committee in Japan Society for Surgical InfectionDepartment of Gastroenterological Surgery, Division of Inflammatory Bowel Disease, Hyogo Medical UniversityDepartment of Surgery and Oncology Graduate School of Medical Sciences, Kyushu UniversityDepartment of Surgery, Hayamizu-Park ClinicDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical SchoolDepartment of Surgery, National Defence Medical CollegeDepartment of Hepatobiliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of MedicineDepartment of Nursing, Division of Surgical Science, Sapporo Medical UniversityDepartment of Nursing, Division of Surgical Science, Sapporo Medical UniversityDepartment of Infectious Disease, Hiroshima University HospitalDepartment of Surgery, Soseikai General HospitalDepartment of Surgery, Toyonaka Municipal HospitalDepartment of Gastrointestinal Surgery, Mie Prefectural General Medical CenterDepartment of Anesthesiology and Critical Care Medicine, Fujita Health UniversityDepartment of Gastrointestinal Surgery, National Center for Geriatrics and GerontologyDepartment of Infection Control, Hospital of the University of Occupational and Environmental HealthDepartment of Anesthesiology, Hokushinkai Megumino HospitalDepartment of Clinical Pharmacokinetics, Research and Education Center for Clinical Pharmacy, Kitasato University HospitalDepartment of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho UniversityDepartment of Dentistry, Hiroshima Prefectural HospitalDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of MedicineDepartment of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, School of Medicine, International University of Health and WelfareDepartment of Intensive Care Unit, Japan Community Healthcare Organization Chukyo HospitalDepartment of Gastroenterological Surgery, Division of Inflammatory Bowel Disease, Hyogo Medical UniversityAbstract Background Surgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy of antiseptic/antibiotic solution during wound irrigation or peritoneal lavage in gastroenterological surgery. Methods The database search used PubMed, MEDLINE, and Cochrane Library. The following inclusion criteria were set for the systematic review. 1) Studies comparing with or without antiseptic/antibiotic irrigation/lavage during gastrointestinal surgery. 2) Studies that described surgical site infections and adverse events. 3) Studies conducted after 2000. Results A total of 8 randomized controlled studies (RCTs) and 3 observational studies were included in this meta-analysis. Three RCTs of wound irrigation with povidone iodine (PVI) solution revealed no significant difference between the PVI and control groups [RR 1.41, 95% CI (0.92 to 2.17): p = 0.69]. Three RCTs of peritoneal lavage with antibiotic solution showed no significant difference between the interventional group and control groups [RR 0.39, 95% CI (0.10 to 1.55): p = 0.18]. Regarding other antiseptic or antibiotic solutions, the number of studies and participants were too small for evaluation. Conclusion Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution did not have enough efficacy for preventing SSI during gastroenterological surgery.https://doi.org/10.1186/s12893-025-02774-3Gastrointestinal surgeryMorbiditySurgical site infectionsAntiseptic/antibiotic solutionWound irrigationPeritoneal lavage |
| spellingShingle | Motoi Uchino Koji Tamura Shinsuke Nomura Seiichi Shinji Keita Kouzu Hiroji Shinkawa Tomohiro Ishinuki Toru Mizuguchi Hiroki Ohge Seiji Haji Junzo Shimizu Yasuhiko Mohri Chizuru Yamashita Yuichi Kitagawa Katsunori Suzuki Motomu Kobayash Masahiro Kobayashi Yuki Hanai Hiroshi Nobuhara Hiroki Imaoka Masahiro Yoshida Toshihiko Mayumi Hiroki Ikeuchi on behalf of SSI Prevention Guideline Committee in Japan Society for Surgical Infection Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis BMC Surgery Gastrointestinal surgery Morbidity Surgical site infections Antiseptic/antibiotic solution Wound irrigation Peritoneal lavage |
| title | Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis |
| title_full | Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis |
| title_fullStr | Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis |
| title_full_unstemmed | Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis |
| title_short | Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis |
| title_sort | wound irrigation and peritoneal lavage with antiseptic antibiotic solution before wound closure during gastrointestinal surgery a systematic review and meta analysis |
| topic | Gastrointestinal surgery Morbidity Surgical site infections Antiseptic/antibiotic solution Wound irrigation Peritoneal lavage |
| url | https://doi.org/10.1186/s12893-025-02774-3 |
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