Clinical Features of Miller-Fisher Syndrome in Pregnancy

Miller-Fisher syndrome (MFS) is recognized as a variant of Guillain-Barré syndrome (GBS). MFS is a rare disorder that is characterized by the acute onset of ophthalmoplegia, ataxia, and areflexia/hyporeflexia. MFS has a higher incidence in Asia, where the incidence is estimated to be 18%–26% of GBS...

Full description

Saved in:
Bibliographic Details
Main Authors: Masanori Ono, Hideki Sato, Mayu Shirahashi, Noriko Tomioka, Julia Maeda, Keiko Watanabe, Tomoko Amagata, Toshiyuki Ikeda, Kazumi Yakubo, Tatsuro Fukuiya
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2015/840680
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832560345201246208
author Masanori Ono
Hideki Sato
Mayu Shirahashi
Noriko Tomioka
Julia Maeda
Keiko Watanabe
Tomoko Amagata
Toshiyuki Ikeda
Kazumi Yakubo
Tatsuro Fukuiya
author_facet Masanori Ono
Hideki Sato
Mayu Shirahashi
Noriko Tomioka
Julia Maeda
Keiko Watanabe
Tomoko Amagata
Toshiyuki Ikeda
Kazumi Yakubo
Tatsuro Fukuiya
author_sort Masanori Ono
collection DOAJ
description Miller-Fisher syndrome (MFS) is recognized as a variant of Guillain-Barré syndrome (GBS). MFS is a rare disorder that is characterized by the acute onset of ophthalmoplegia, ataxia, and areflexia/hyporeflexia. MFS has a higher incidence in Asia, where the incidence is estimated to be 18%–26% of GBS compared with 3%–5% in the West. The differential diagnosis of MFS includes Wernicke’s encephalopathy (WE) which is characterized by a clinical triad (nystagmus and ophthalmoplegia, mental status changes, and ataxia), myasthenia gravis, and brainstem stroke. The association between MFS and pregnancy has not been reported previously. Here, we describe the clinical features of a pregnant woman in early pregnancy with MFS. This case highlights the fact that it is necessary to establish an accurate diagnosis based on the details from the patient’s history on appropriate complementary testing in a pregnant patient with MFS.
format Article
id doaj-art-c2b030fddb6e450f984d857adddf1df1
institution Kabale University
issn 2090-6684
2090-6692
language English
publishDate 2015-01-01
publisher Wiley
record_format Article
series Case Reports in Obstetrics and Gynecology
spelling doaj-art-c2b030fddb6e450f984d857adddf1df12025-02-03T01:27:53ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922015-01-01201510.1155/2015/840680840680Clinical Features of Miller-Fisher Syndrome in PregnancyMasanori Ono0Hideki Sato1Mayu Shirahashi2Noriko Tomioka3Julia Maeda4Keiko Watanabe5Tomoko Amagata6Toshiyuki Ikeda7Kazumi Yakubo8Tatsuro Fukuiya9Department of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Neurology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, JapanMiller-Fisher syndrome (MFS) is recognized as a variant of Guillain-Barré syndrome (GBS). MFS is a rare disorder that is characterized by the acute onset of ophthalmoplegia, ataxia, and areflexia/hyporeflexia. MFS has a higher incidence in Asia, where the incidence is estimated to be 18%–26% of GBS compared with 3%–5% in the West. The differential diagnosis of MFS includes Wernicke’s encephalopathy (WE) which is characterized by a clinical triad (nystagmus and ophthalmoplegia, mental status changes, and ataxia), myasthenia gravis, and brainstem stroke. The association between MFS and pregnancy has not been reported previously. Here, we describe the clinical features of a pregnant woman in early pregnancy with MFS. This case highlights the fact that it is necessary to establish an accurate diagnosis based on the details from the patient’s history on appropriate complementary testing in a pregnant patient with MFS.http://dx.doi.org/10.1155/2015/840680
spellingShingle Masanori Ono
Hideki Sato
Mayu Shirahashi
Noriko Tomioka
Julia Maeda
Keiko Watanabe
Tomoko Amagata
Toshiyuki Ikeda
Kazumi Yakubo
Tatsuro Fukuiya
Clinical Features of Miller-Fisher Syndrome in Pregnancy
Case Reports in Obstetrics and Gynecology
title Clinical Features of Miller-Fisher Syndrome in Pregnancy
title_full Clinical Features of Miller-Fisher Syndrome in Pregnancy
title_fullStr Clinical Features of Miller-Fisher Syndrome in Pregnancy
title_full_unstemmed Clinical Features of Miller-Fisher Syndrome in Pregnancy
title_short Clinical Features of Miller-Fisher Syndrome in Pregnancy
title_sort clinical features of miller fisher syndrome in pregnancy
url http://dx.doi.org/10.1155/2015/840680
work_keys_str_mv AT masanoriono clinicalfeaturesofmillerfishersyndromeinpregnancy
AT hidekisato clinicalfeaturesofmillerfishersyndromeinpregnancy
AT mayushirahashi clinicalfeaturesofmillerfishersyndromeinpregnancy
AT norikotomioka clinicalfeaturesofmillerfishersyndromeinpregnancy
AT juliamaeda clinicalfeaturesofmillerfishersyndromeinpregnancy
AT keikowatanabe clinicalfeaturesofmillerfishersyndromeinpregnancy
AT tomokoamagata clinicalfeaturesofmillerfishersyndromeinpregnancy
AT toshiyukiikeda clinicalfeaturesofmillerfishersyndromeinpregnancy
AT kazumiyakubo clinicalfeaturesofmillerfishersyndromeinpregnancy
AT tatsurofukuiya clinicalfeaturesofmillerfishersyndromeinpregnancy