Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period
Coronaviruses can cause damage to various parts of the respiratory system, gastrointestinal tract, and other organs and systems.The aim of the study: to monitor the circulation of seasonal coronaviruses in hospitalized children in the pre-pandemic period.Materials and methods: real-time multiplex PC...
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| Format: | Article |
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LLC "Diagnostics and Vaccines"
2021-04-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/564 |
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| author | V. N. Timchenko V. F. Sukhovetskaya T. M. Chernova T. A. Kaplina M. D. Subbotina O. V. Bulina М. М. Pisareva |
| author_facet | V. N. Timchenko V. F. Sukhovetskaya T. M. Chernova T. A. Kaplina M. D. Subbotina O. V. Bulina М. М. Pisareva |
| author_sort | V. N. Timchenko |
| collection | DOAJ |
| description | Coronaviruses can cause damage to various parts of the respiratory system, gastrointestinal tract, and other organs and systems.The aim of the study: to monitor the circulation of seasonal coronaviruses in hospitalized children in the pre-pandemic period.Materials and methods: real-time multiplex PCR was used to test samples of nasopharyngeal mucus from 2188 patients aged 1 monthto 17 years, hospitalized with acute respiratory infection in 2014—2018. The results are presented with the indication of the fractions (%) and the calculation of the 95% confidence interval according to Klopper-Pearson. The differences between the groups were evaluated using the Pearson χ2 test. The differences in the groups were considered statistically significant at the level of the criterion p< 0.05.Results: monitoring of the circulation of pathogens of acute respiratory viral infection (ARVI) during 5 epidemic seasons showed that the appearance of a new subtype of coronavirus in 2019 was preceded by a gradual displacement of influenza, RS-and bocavirus infections from the circulation due to a statistically significant increase in the proportion of seasonal coronaviruses from 3.6% in 2014—2015 to 10.8% in the prepandemic season 2018—2019 (p= 0.007). The circulation of seasonal coronaviruses had a distinct seasonality (november-april)with the peak of registration in february (28.4%) and march (36.7%). Seasonal coronaviruses were detected in 7.3% of hospitalized children with ARVI, with a predominance in the age groups under 2 years (58.2%) and 3—6 years (25.4%). Hospitalization was more often required for patients with lower respiratory tract lesions (58.2%), a fifth of which was pneumonia (21.8%). In most children, ARVI caused by coronaviruses occurred as a monoinfection (79.9%), combined infection with other pathogens was observed in 20.1% of cases with fluctuations from 18.2% to 28.6% in different epidemic seasons. Viral associations are most common in young children (85.2%). |
| format | Article |
| id | doaj-art-c2a6e29a047542edab28f5d3d10593af |
| institution | OA Journals |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-c2a6e29a047542edab28f5d3d10593af2025-08-20T02:02:51ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072021-04-0120151110.22627/2072-8107-2021-20-1-5-11481Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic periodV. N. Timchenko0V. F. Sukhovetskaya1T. M. Chernova2T. A. Kaplina3M. D. Subbotina4O. V. Bulina5М. М. Pisareva6Saint-Petersburg State Pediatric Medical University, Saint-PetersburgSaint-Petersburg State Pediatric Medical University, Saint-PetersburgSaint-Petersburg State Pediatric Medical University, Saint-PetersburgSaint-Petersburg State Pediatric Medical University, Saint-PetersburgSaint-Petersburg State Pediatric Medical University, Saint-PetersburgSaint-Petersburg State Pediatric Medical University, Saint-PetersburgScientific Research Institute of Influenza named after A.A. Smorodintseva of the Ministry of Health of the Russian FederationCoronaviruses can cause damage to various parts of the respiratory system, gastrointestinal tract, and other organs and systems.The aim of the study: to monitor the circulation of seasonal coronaviruses in hospitalized children in the pre-pandemic period.Materials and methods: real-time multiplex PCR was used to test samples of nasopharyngeal mucus from 2188 patients aged 1 monthto 17 years, hospitalized with acute respiratory infection in 2014—2018. The results are presented with the indication of the fractions (%) and the calculation of the 95% confidence interval according to Klopper-Pearson. The differences between the groups were evaluated using the Pearson χ2 test. The differences in the groups were considered statistically significant at the level of the criterion p< 0.05.Results: monitoring of the circulation of pathogens of acute respiratory viral infection (ARVI) during 5 epidemic seasons showed that the appearance of a new subtype of coronavirus in 2019 was preceded by a gradual displacement of influenza, RS-and bocavirus infections from the circulation due to a statistically significant increase in the proportion of seasonal coronaviruses from 3.6% in 2014—2015 to 10.8% in the prepandemic season 2018—2019 (p= 0.007). The circulation of seasonal coronaviruses had a distinct seasonality (november-april)with the peak of registration in february (28.4%) and march (36.7%). Seasonal coronaviruses were detected in 7.3% of hospitalized children with ARVI, with a predominance in the age groups under 2 years (58.2%) and 3—6 years (25.4%). Hospitalization was more often required for patients with lower respiratory tract lesions (58.2%), a fifth of which was pneumonia (21.8%). In most children, ARVI caused by coronaviruses occurred as a monoinfection (79.9%), combined infection with other pathogens was observed in 20.1% of cases with fluctuations from 18.2% to 28.6% in different epidemic seasons. Viral associations are most common in young children (85.2%).https://detinf.elpub.ru/jour/article/view/564childrenseasonal coronavirusespcrseasonalityacute respiratory viral infection |
| spellingShingle | V. N. Timchenko V. F. Sukhovetskaya T. M. Chernova T. A. Kaplina M. D. Subbotina O. V. Bulina М. М. Pisareva Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period Детские инфекции (Москва) children seasonal coronaviruses pcr seasonality acute respiratory viral infection |
| title | Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period |
| title_full | Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period |
| title_fullStr | Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period |
| title_full_unstemmed | Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period |
| title_short | Results of 5-year monitoring of the circulation of seasonal Сoronaviruses in hospitalized children in the pre-pandemic period |
| title_sort | results of 5 year monitoring of the circulation of seasonal сoronaviruses in hospitalized children in the pre pandemic period |
| topic | children seasonal coronaviruses pcr seasonality acute respiratory viral infection |
| url | https://detinf.elpub.ru/jour/article/view/564 |
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