Health utility value of overactive bladder in Japanese older adults
Abstract Objectives To determine the health utility values (HUVs) of overactive bladder (OAB), defined as urinary urgency, usually accompanied by urinary daytime or nocturnal frequency, with or without urinary incontinence, among adults aged ≥65 years and to assess the HUV decrements (disutilities)...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | BJUI Compass |
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| Online Access: | https://doi.org/10.1002/bco2.471 |
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| author | Takashi Yoshioka Kenji Omae Satoshi Funada Tetsuji Minami Rei Goto |
| author_facet | Takashi Yoshioka Kenji Omae Satoshi Funada Tetsuji Minami Rei Goto |
| author_sort | Takashi Yoshioka |
| collection | DOAJ |
| description | Abstract Objectives To determine the health utility values (HUVs) of overactive bladder (OAB), defined as urinary urgency, usually accompanied by urinary daytime or nocturnal frequency, with or without urinary incontinence, among adults aged ≥65 years and to assess the HUV decrements (disutilities) of OAB according to its severity. Methods This cross‐sectional Internet‐based study was conducted between 2 and 9 November 2023, with quota sampling with equal probability for each sex and age group (age 65–74 years and ≥75 years). OAB was defined as an urgency score of ≥2 points and a total score of ≥3 points based on the Overactive Bladder Symptom Score. OAB severity was categorized as mild (total score, ≤5 points) or moderate‐to‐severe (total score, 6–15 points). HUVs were measured using the EuroQol five‐dimension five‐level value set for the Japanese population. Multivariable linear regression models were fitted to estimate the covariate‐adjusted disutilities of OAB. We selected eight covariates (age, sex, body mass index, education, income, smoking, alcohol use, and comorbidities) as potential confounders based on previous studies. The sample size was determined based on previous studies without statistical power calculations. Results Among the 998 participants (51.9% male; mean age, 73.2 years), 158 (15.9%) had OAB, of whom 87 (8.8%) had moderate‐to‐severe OAB. The mean HUVs for participants with mild and moderate‐to‐severe OAB were 0.874 and 0.840, respectively, which were lower compared with the HUV for those without OAB (0.913). After adjusting for relevant covariates, disutilities (95% confidence intervals [CIs] and p values) for mild and moderate‐to‐severe OAB were −0.0334 (−0.0602 to −0.0066, p = 0.014) and −0.0591 (−0.0844 to −0.0339, p < 0.001), respectively. Conclusions Consistent with previous HUV studies on OAB, our results demonstrated that the prevalence of OAB was associated with substantially lower HUV. The results demonstrate that increased OAB severity is associated with greater disutility. |
| format | Article |
| id | doaj-art-c29c4067212c427ca6773a7f511eb8db |
| institution | Kabale University |
| issn | 2688-4526 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | BJUI Compass |
| spelling | doaj-art-c29c4067212c427ca6773a7f511eb8db2025-01-31T00:14:32ZengWileyBJUI Compass2688-45262025-01-0161n/an/a10.1002/bco2.471Health utility value of overactive bladder in Japanese older adultsTakashi Yoshioka0Kenji Omae1Satoshi Funada2Tetsuji Minami3Rei Goto4Health Technology Assessment Unit, Department of Preventive Medicine and Public Health Keio University School of Medicine Tokyo JapanDepartment of Innovative Research and Education for Clinicians and Trainees (DiRECT) Fukushima Medical University Hospital Fukushima JapanHealth Technology Assessment Unit, Department of Preventive Medicine and Public Health Keio University School of Medicine Tokyo JapanDivision of Quality Assurance Programs Institute for Cancer Control, National Cancer Center Tokyo JapanGraduate School of Health Management Keio University Kanagawa JapanAbstract Objectives To determine the health utility values (HUVs) of overactive bladder (OAB), defined as urinary urgency, usually accompanied by urinary daytime or nocturnal frequency, with or without urinary incontinence, among adults aged ≥65 years and to assess the HUV decrements (disutilities) of OAB according to its severity. Methods This cross‐sectional Internet‐based study was conducted between 2 and 9 November 2023, with quota sampling with equal probability for each sex and age group (age 65–74 years and ≥75 years). OAB was defined as an urgency score of ≥2 points and a total score of ≥3 points based on the Overactive Bladder Symptom Score. OAB severity was categorized as mild (total score, ≤5 points) or moderate‐to‐severe (total score, 6–15 points). HUVs were measured using the EuroQol five‐dimension five‐level value set for the Japanese population. Multivariable linear regression models were fitted to estimate the covariate‐adjusted disutilities of OAB. We selected eight covariates (age, sex, body mass index, education, income, smoking, alcohol use, and comorbidities) as potential confounders based on previous studies. The sample size was determined based on previous studies without statistical power calculations. Results Among the 998 participants (51.9% male; mean age, 73.2 years), 158 (15.9%) had OAB, of whom 87 (8.8%) had moderate‐to‐severe OAB. The mean HUVs for participants with mild and moderate‐to‐severe OAB were 0.874 and 0.840, respectively, which were lower compared with the HUV for those without OAB (0.913). After adjusting for relevant covariates, disutilities (95% confidence intervals [CIs] and p values) for mild and moderate‐to‐severe OAB were −0.0334 (−0.0602 to −0.0066, p = 0.014) and −0.0591 (−0.0844 to −0.0339, p < 0.001), respectively. Conclusions Consistent with previous HUV studies on OAB, our results demonstrated that the prevalence of OAB was associated with substantially lower HUV. The results demonstrate that increased OAB severity is associated with greater disutility.https://doi.org/10.1002/bco2.471health economic evaluationhealth utilityhealth‐related quality of lifelower urinary tract symptomsoveractive bladder |
| spellingShingle | Takashi Yoshioka Kenji Omae Satoshi Funada Tetsuji Minami Rei Goto Health utility value of overactive bladder in Japanese older adults BJUI Compass health economic evaluation health utility health‐related quality of life lower urinary tract symptoms overactive bladder |
| title | Health utility value of overactive bladder in Japanese older adults |
| title_full | Health utility value of overactive bladder in Japanese older adults |
| title_fullStr | Health utility value of overactive bladder in Japanese older adults |
| title_full_unstemmed | Health utility value of overactive bladder in Japanese older adults |
| title_short | Health utility value of overactive bladder in Japanese older adults |
| title_sort | health utility value of overactive bladder in japanese older adults |
| topic | health economic evaluation health utility health‐related quality of life lower urinary tract symptoms overactive bladder |
| url | https://doi.org/10.1002/bco2.471 |
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