New insights into the structure domain and function of NLR family CARD domain containing 5

New insights into the structure domain and function of NLR family CARD domain containing 5

Abstract NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization...

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Bibliographic Details
Main Authors: Haiqing Zhu, Chengwei Xiao, Jiahua Chen, Bao Guo, Wenyan Wang, Zhenhai Tang, Yunxia Cao, Lei Zhan, Jun-hui Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
NLRC5
Structural domain
MHC I
Immunity
Tumour
PRR
Online Access:https://doi.org/10.1186/s12964-024-02012-y
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