New insights into the structure domain and function of NLR family CARD domain containing 5
Abstract NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-024-02012-y |
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| author | Haiqing Zhu Chengwei Xiao Jiahua Chen Bao Guo Wenyan Wang Zhenhai Tang Yunxia Cao Lei Zhan Jun-hui Zhang |
| author_facet | Haiqing Zhu Chengwei Xiao Jiahua Chen Bao Guo Wenyan Wang Zhenhai Tang Yunxia Cao Lei Zhan Jun-hui Zhang |
| author_sort | Haiqing Zhu |
| collection | DOAJ |
| description | Abstract NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization domain (NOD or NACHT), and a leucine-rich repeat (LRR) domain. The functional variability of NLRC5 has been attributed to its different domain interactions with specific ligands in different cell types. In this review, we address the molecular mechanisms and their implications in multiple microenvironments based on the different functional domains of NLRC5. |
| format | Article |
| id | doaj-art-c29b41f4dc6c4b0ea4851cad3daa40ac |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-c29b41f4dc6c4b0ea4851cad3daa40ac2025-01-26T12:44:49ZengBMCCell Communication and Signaling1478-811X2025-01-0123111810.1186/s12964-024-02012-yNew insights into the structure domain and function of NLR family CARD domain containing 5Haiqing Zhu0Chengwei Xiao1Jiahua Chen2Bao Guo3Wenyan Wang4Zhenhai Tang5Yunxia Cao6Lei Zhan7Jun-hui Zhang8The Second Affiliated Hospital of Anhui Medical UniversityThe Second Affiliated Hospital of Bengbu Medical UniversityThe Second Affiliated Hospital of Anhui Medical UniversityThe Second Affiliated Hospital of Anhui Medical UniversityThe Second Affiliated Hospital of Anhui Medical UniversityCenter for Scientific Research of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe Second Affiliated Hospital of Anhui Medical UniversityAbstract NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization domain (NOD or NACHT), and a leucine-rich repeat (LRR) domain. The functional variability of NLRC5 has been attributed to its different domain interactions with specific ligands in different cell types. In this review, we address the molecular mechanisms and their implications in multiple microenvironments based on the different functional domains of NLRC5.https://doi.org/10.1186/s12964-024-02012-yNLRC5Structural domainMHC IImmunityTumourPRR |
| spellingShingle | Haiqing Zhu Chengwei Xiao Jiahua Chen Bao Guo Wenyan Wang Zhenhai Tang Yunxia Cao Lei Zhan Jun-hui Zhang New insights into the structure domain and function of NLR family CARD domain containing 5 Cell Communication and Signaling NLRC5 Structural domain MHC I Immunity Tumour PRR |
| title | New insights into the structure domain and function of NLR family CARD domain containing 5 |
| title_full | New insights into the structure domain and function of NLR family CARD domain containing 5 |
| title_fullStr | New insights into the structure domain and function of NLR family CARD domain containing 5 |
| title_full_unstemmed | New insights into the structure domain and function of NLR family CARD domain containing 5 |
| title_short | New insights into the structure domain and function of NLR family CARD domain containing 5 |
| title_sort | new insights into the structure domain and function of nlr family card domain containing 5 |
| topic | NLRC5 Structural domain MHC I Immunity Tumour PRR |
| url | https://doi.org/10.1186/s12964-024-02012-y |
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